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Endothelial Barriers

  • Kenneth L. Audus
Part of the NATO ASI Series book series (NSSA, volume 218)

Abstract

The endothelial cells lining the vasculature comprise an interface elaborated for controlling the distribution of substances between the blood and the interstitial fluid. Additionally, this interface performs synthetic, degradative, and receptor functions that vary greatly, depending on the location and nature of the surrounding tissue. Consequently, endothelia are currently understood to be a dynamic, heterogenous population of cells. Many of the functions of the endothelial cell have direct relevance to the pharmaceutical chemist’s goal of providing selective, efficient, and effective delivery of therapeutic substances to tissue target sites. The purpose of this review is to briefly detail the cell biology of vascular endothelium and properties of these cells that one desires in a cell culture system appropriate for addressing problems in pharmaceutical chemistry.

Keywords

Bovine Brain Tissue Culture System Brain Capillary Endothelial Cell Brain Microvessel Endothelial Cell Tight Intercellular Junction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kenneth L. Audus
    • 1
  1. 1.Department of Pharmaceutical ChemistryThe University of Kansas School of PharmacyLawrenceUSA

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