Recombinant Gamma Interferon as an Immunological Adjuvant
Given the substantial advances that have been made in the understanding of how immune responses are induced and regulated, it should be possible to design vaccine adjuvants deliberately rather than empirically. This approach has led to the demonstration that at least three of the cytokines involved in interactions between immunological cells have significant adjuvant properties when given together with antigen.
KeywordsMalaria Vaccine Adjuvant Activity Immunological Cell Adjuvant Property Recombinant Gamma Interferon
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- Anderson, G., Urban, U., Fedorka-Cray, P., Newell, A., Nunberg, J. and Doyle, M., 1987, Interleukin 2 and protective immunity in Haemophilus pleuropneumoniae: preliminary studies, in: “Vaccines’ 87”, R.M. Chanock, R.A. Lerner, F. Brown and H. Ginsberg, eds., Cold Spring Harbor Laboratory Symposia.Google Scholar
- Harte, P.G., De Souza, J.B. and Playfair, J.H.L., 1982, Failure of malaria vaccination in mice born to immune mothers, Clin. Exp. Imm., 49: 509.Google Scholar
- Skoglund, C., Scheynius, A., Holmdahl, R. and Van der Meide, P.H., 1988, Enhancement of DTH reaction and inhibition of the expression of class II transplantation antigens by in vivo treatment with antibodies against IFN-γ, Clin. Exp. Imm., 71: 428.Google Scholar
- Staruch, M.J. and Wood, D.D., 1983, The adjuvanticity of interleukin 1 in vivo, J. Immunol., 130: 2191.Google Scholar
- Strassmann, G., Somers, S.D., Spencer, T.D., Adams D.O. and Hamilton, T.A., 1986, Biochemical models of interferonγ mediated macrophage activation; independent regulation of lymphocyte function associated antigen (LFA-1) and Ia antigen on murine peritoneal macrophages, Cell. Immunol., 97: 110.PubMedCrossRefGoogle Scholar