Structural and Functional Studies on MHC-Peptide Antigen Interactions
T cells recognize protein antigens on the surface of antigen presenting cells (APC), but only after the antigen has been “processed” (physically altered by denaturation or fragmentation) by an APC (Shimonkevitz et al, 1983) and subsequently “displayed” in association with MC molecules on the APC surface (Allen et al, 1987; Buus et al, 1987b). Previous studies on the mechanism of antigen recognition have established that T cells recognize a complex formed between MHC and peptide fragments of protein antigens (Werdelein 1982; Watts et al, 1984; Buus et al, 1986). Moreover, a strong correlation exists between the capacity to form complexes with peptides and the capacity to serve as the MHC restriction element used in the immune response to the same peptides (Babbitt et al, 1985; Buus et al, 1987a).
KeywordsMajor Histocompatibility Complex Protein Antigen Basic Residue Major Histocompatibility Complex Molecule Cell Repertoire
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- Klein, J., 1982, “Immunology”, John Wiley & Sons, New York.Google Scholar
- Paul, W., 1984, “Fundamental Immunology”, Raven Press, New York.Google Scholar
- Sette, A., Buus, S., Colon, S., Miles, C. and Grey, H.M., 1988, Structural analysis of peptides capable of binding to more than one Ia antigen, J. Immunol, in press.Google Scholar