Structural and Functional Studies on MHC-Peptide Antigen Interactions

  • Howard M. Grey
  • Søren Buus
  • Alessandro Sette
Part of the NATO ASI Series book series (NSSA, volume 179)


T cells recognize protein antigens on the surface of antigen presenting cells (APC), but only after the antigen has been “processed” (physically altered by denaturation or fragmentation) by an APC (Shimonkevitz et al, 1983) and subsequently “displayed” in association with MC molecules on the APC surface (Allen et al, 1987; Buus et al, 1987b). Previous studies on the mechanism of antigen recognition have established that T cells recognize a complex formed between MHC and peptide fragments of protein antigens (Werdelein 1982; Watts et al, 1984; Buus et al, 1986). Moreover, a strong correlation exists between the capacity to form complexes with peptides and the capacity to serve as the MHC restriction element used in the immune response to the same peptides (Babbitt et al, 1985; Buus et al, 1987a).


Major Histocompatibility Complex Protein Antigen Basic Residue Major Histocompatibility Complex Molecule Cell Repertoire 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adorini, L., Sette, A., Buus, S., Grey, H.M., Darsley, M., Lehmann, P.V., Doria, G., Nagy, Z.A. and Appella, E., 1988, Interaction of an immunodominant epitope with Ia molecules in T-cell activation, Proc.Natl.Acad.Sci.USA., 85: 5181.PubMedCrossRefGoogle Scholar
  2. Allen, P.M., Babbitt, B. and Unanue, E., 1987, T cell recognition of lysozyme — the biochemical basis of presentation, Immunol.Rev., 98: 172.CrossRefGoogle Scholar
  3. Babbittt, B., Allen, P., Matsueda, G., Haber, E. and Unanue, E., 1985, The binding of immunogenic peptides to Ia histocompatibility molecules, Nature, 317: 359.CrossRefGoogle Scholar
  4. Buus, S., Sette, A., Colon, S.M., Jenis, D.M. and Grey, H.M., 1986, Isolation and characterization of antigen-la complexes involved in T cell recognition, Cell, 47: 1071.PubMedCrossRefGoogle Scholar
  5. Buus, S., Sette, A., Colon, S.M., Miles, C. and Grey, H.M., 1987a, The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides, Science, 235: 1352.CrossRefGoogle Scholar
  6. Buus, S., Sette, A. and Grey, H.M., 1987b, The interaction between proteinderived immunogenic peptides and Ia, Immunol.Rev., 98: 115.PubMedCrossRefGoogle Scholar
  7. Finnegan, A., Smith, M.A., Smith, J.A., Berzofsky, J., Sachs, D.H. and Hodes, R.J., 1986, The T cell repertoire for recognition of a phylogenetically distant protein antigen, J.Exp.Med., 164: 897.PubMedCrossRefGoogle Scholar
  8. Guillet, J., Lai, M., Briner, T.J., Buus, S., Sette, A., Grey, H.M., Smith, J.A. and Gefter, M., 1987, Immunological self, nonself discrimination, Science, 235: 1353.CrossRefGoogle Scholar
  9. Klein, J., 1982, “Immunology”, John Wiley & Sons, New York.Google Scholar
  10. Paul, W., 1984, “Fundamental Immunology”, Raven Press, New York.Google Scholar
  11. Rosenthal, A.S., 1978, Determinant selection and macrophage function in genetic control of the immune response, Immunol.Rev., 40: 136.PubMedCrossRefGoogle Scholar
  12. Sette, A., Buus, S., Colon, S., Miles, C. and Grey, H.M., 1988, Structural analysis of peptides capable of binding to more than one Ia antigen, J. Immunol, in press.Google Scholar
  13. Shimonkevitz, R., Kappler, J., Marrack, P. and Grey, H., 1983, Antigen recognition by H-2 restricted T cells, J.Exp.Med., 158: 303.PubMedCrossRefGoogle Scholar
  14. Watts, T.H., Brian, A.A., Kappler, J.W., Marrack, P. and McConnell, H.M., 1984, Antigen presentation by supported planar membranes containing affinity purified I-Ad, Proc.Natl.Acad.Sci.USA., 81: 7564.PubMedCrossRefGoogle Scholar
  15. Werdelin, O.J., 1982, Chemically related antigens compete for presentation by accessory cells to T cells, J. Immunol., 129: 1883.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Howard M. Grey
    • 1
  • Søren Buus
    • 2
  • Alessandro Sette
    • 1
  1. 1.CytelSan DiegoUSA
  2. 2.Uhiversity of CopenhagenCopenhagenDenmark

Personalised recommendations