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The Development and Preliminary Clinical Evaluation of an Antifertility Vaccine

  • P.D. Griffin
Part of the NATO ASI Series book series (NSSA, volume 179)

Abstract

The World Health Organization’s Special Programme of Research, Development and Research Training in Human Reproduction is a global programme of international technical cooperation initiated by WHO to promote, coordinate, support, conduct and evaluate research in human reproduction with special reference to the needs of developing countries, by:
  1. (a)

    promoting and supporting research aimed at finding and developing new safe, effective and acceptable methods of fertility regulation as well as identifying and eliminating obstacles to such research and development;

     
  2. (b)

    identifying and evaluating health and safety problems associated with fertility regulation technology, analysing the behavioural and social determinants of fertility regulation, and testing cost-effective interventions to develop improved approaches to fertility regulation within the context of reproductive health services;

     
  3. (c)

    strengthening the training and research capability of developing countries to conduct research in the field of human reproduction;

     
  4. (d)

    establishing a basis for collaboration with other programmes engaged in research and development in human reproduction, including the identification of priorities across the field and the coordination of activities in the light of such priorities (Barzelatto, 1988).

     

Keywords

Human Chorionic Gonadotrophin Human Reproduction Diphtheria Toxoid Muramyl Dipeptide Fertility Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barzelatto, J., 1988, World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction, Biennial Report 1986–1987, W.H.O., 11.Google Scholar
  2. Griffin, P.D., 1986, A fertility regulating vaccine based on the carboxyl-terminal peptide of the beta subunit of hCG, in: “Immunological Approaches to Contraception and Promotion of Fertility”, G.P. Talwar, ed., Plenum Publishing Corporation.Google Scholar
  3. Griffin, P.D., 1988, World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction, Biennial Report 1986–1987, W.H.O., 177.Google Scholar
  4. Hearn, J.P., 1976, Immunization against pregnancy, Proc.Roy.Soc.London (Biology), 195: 149.CrossRefGoogle Scholar
  5. Jones, W.R., Bradley, J., Judd, S.J., Denholm, E.H., Ing, R.M.Y., Mueller, U.W., Powell, J.H., Griffin, P.D., Stevens, V.C., 1988, Phase I clinical trial of a World Health Organization birth control vaccine, Lancet, 8598: 1295.CrossRefGoogle Scholar
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  7. Stevens, V.C., 1975, Antifertility effects fron immunization with intact, subunits and fragments of hCG, in: “Physiological Effects of Immunity Against Reproductive Hormones”, R.G. Edwards, M.H. Johnson, eds., Cambridge University Press.Google Scholar
  8. Stevens, V.C., Cinader, B., Powell, J.H., Lee, A.C., Koh, S.W., 1981a, Preparation and formulation of a human chorionic gonadotrophin antifertility vaccine: selection of a peptide immunogen, Amer.J.Reprod. Immun., 1: 307.Google Scholar
  9. Stevens, V.C., Cinader, B., Powell, J.H., Lee, A.C., Koh, S.W., 1981b, Preparation and formulation of a human chorionic gonadotrophin antifertility vaccine: selection of adjuvant and vehicle. Amer.J.Reprod. Immun., 1: 315.Google Scholar
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • P.D. Griffin
    • 1
  1. 1.Special Programme of Research, Development and Research Training in Human ReproductionWorld Health OrganizationGeneva 27Switzerland

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