Synthetic Antigens and Vaccines
Early studies in our laboratory have demonstrated that synthetic antigens containing an immunoreactive region of a protein can give rise to a specific, and often conformation-dependent, immune response towards the intact native protein (Arnon et al, 1971). When the protein in question is a component of a virus e.g. the coat protein of MS-2 coliphage, the antibodies induced by a synthetic fragment were capable of neutralizing the viability of the phage (Langbeheim et al, 1976). These findings paved the way for the study of synthetic vaccines. We have employed this approach for the study of three systems — the influenza virus and the bacterial toxins of cholera and shigella. The results achieved to date as well as the future prospects of these three synthetic vaccines are discussed below.
KeywordsInfluenza Virus Synthetic Peptide Cholera Toxin Tetanus Toxoid Antigenic Site
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