The Immunoadjuvant Action of Liposomes: Role of Structural Characteristics

  • Gregory Gregoriadis
  • Lloyd Tan
  • Qifu Xiao
Part of the NATO ASI Series book series (NSSA, volume 179)


Initial observations on the immunoadjuvant properties of liposomes (Allison and Gregoriadis, 1974; Gregoriadis and Allison, 1974) have been now confirmed and extended using a variety of antigens relevant to human and veterinary immunization (for reviews see Gregoriadis, 1988). Antigens studied in conjunction with liposomes include Streptococcus pneumoniae serovar 3 (Snippe et al, 1983), Salmonella typhimurium lipopolysaccharide (Desiderio and Campbell, 1985), cholera toxin (Alving et al, 1980; Pierce and Sacci, 1984), adenovirus type 5 hexon (Kramp et al, 1982), Herpes Simplex virus type 1 antigens (Naylor et al, 1982), hepatitis B virus surface antigen (Manesis et al, 1979), Epstein-Barr virus gp 340 protein (Epstein et al, 1985), tetanus toxioid (Davis et al, 1986; Gregoriadis et al, 1987), synthetic peptides of foot-and-mouth disease virus (Francis et al, 1985), poliovirus peptides (Xiao et al, 1989) and rat spermatozoal polypeptide fraction (Mettler et al, 1983).


Tetanus Toxoid Primary Immune Response Small Unilamellar Vesicle Secondary Immune Response Free Bovine Serum Albumin 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Gregory Gregoriadis
    • 1
  • Lloyd Tan
    • 1
  • Qifu Xiao
    • 1
  1. 1.Medical Research Council Group, Academic Department of MedicineRoyal Free Hospital School of MedicineLondonUK

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