Advertisement

Effects of Lithium Chloride on Human and Murine Marrow Myeloid Colony Formation and Colony Stimulating Activity

  • Peter L. Greenberg
  • Beverly Packard
  • Susan M. Steed
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Abstract

Prior studies have indicated that oral administration of lithium salts causes neutrophilia due to increased granulopoiesis in normal individuals and in some patients with hematologic disorders (Gupta et al., 1976; Malloy et al., 1978; Rothstein et al., 1978). Controversy exists regarding the mechanism whereby lithium exerts this granulopoietic effect. Studies in mice have demonstrated that production of colony stimulating activity (CSA) by extramedullary cell sources (e.g. lung) is enhanced following in vitro exposure to lithium (Harker et al., 1977). Studies with human cells have reported both increased CSA production by peripheral blood leukocytes (Joyce and Chervenick, 1975) and an adjuvant effect on granulopoietic precursor cells (in vitro colony forming cells, CFU-C) (Morley and Galbraith, 1978). Increased urinary and serum CSA levels occur following in vivo administration of lithium (Gupta et al., 1976); however, these sources of CSA are stimulatory for murine but not human marrow CFU-C in vitro.

Keywords

Acute Myeloid Leukemia Conditioned Medium Lithium Chloride Lithium Salt Human Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Broxmeyer, H., Moore, M., and Ralph, P., 1977, Cell-free granulocyte colony inhibiting activity derived from human polymorphonuclear neutrophils, Exp. Hematol. 5:87.PubMedGoogle Scholar
  2. Burgess, A.W., Wilson, E.M.A., and Metcalf, D., 1977, Stimulation by human placental conditioned medium of hemopoietic colony formation by human marrow cells, Blood 49:573.PubMedGoogle Scholar
  3. Chan, S., and Metcalf, D., 1972, Local production of colony stumulating factor within the bone marrow: Role of nonhemopoietic cells, Blood 40:646.PubMedGoogle Scholar
  4. Chan, S., and Metcalf, D., 1973, Local and systemic control of granulocytic and macrophagic progenitor cell regeneration after irradiation, Cell Tissue Kinet. 6:185.PubMedGoogle Scholar
  5. Greenberg, P.L., and Mosny, S.A., 1977, Inhibitory effects in vitro of interf eron on human and murine granulocytic progenitor cells, Cancer Res. 37:1794.PubMedGoogle Scholar
  6. Greenberg, P.L., Mara, B., and Heller, P., 1978, Marrow cell colony stimulating activity in acute myeloid leukemia, Blood 52:362.PubMedGoogle Scholar
  7. Greenberg, P.L., Packard, B., and Steed, S.M., 1979, Granulopoietic effects of lithium on marrow myeioid cells, manuscript in preparation.Google Scholar
  8. Gupta, R., Robinson, W., and Kurnick, J., 1976, Felty’s syndrome: Effect of lithium on granulopoiesis, Am. J. Med. 61:29.PubMedCrossRefGoogle Scholar
  9. Harker, W.G., Rothstein, G., Clarkson, D., and Athens, J., 1977, Enhancement of colony-stimulating activity production by lithium, Blood 49:263.PubMedGoogle Scholar
  10. Haskill, J., McKnight, R., and Galbraith, P., 1972, Cell-cell interaction in vitro: Studied by density separation of colony forming, stimulating, and inhibiting cells from bone marrow, Blood 40:394.PubMedGoogle Scholar
  11. Joyce, R., and Chervenick, P., 1975, Effect of lithium on the release of colony stimulating activity from blood leukocytes, Proc. Am. Soc. Hematol. (December, 1975), p. 126.Google Scholar
  12. Kurland, J., Hadden, J., and Moore, M.A.S., 1977, Role of cyclic nucleotides in the proliferation of committed granulocyte-macrophage progenitor cells, Cancer Res, 37:4534.PubMedGoogle Scholar
  13. Malloy, N., Zauber, N., and Chervenick, P., 1978, The effect of lithium on blood and marrow neutrophils, Proc. Am. Soc. Hematol. (December, 1978), p. 228.Google Scholar
  14. Morley, D., and Galbraith, P., 1978, Effect of lithium on granulopoiesis in culture, Can. Med. Assn. Journal 118:288.Google Scholar
  15. Oshita, A., Rothstein, G., and Lonngi, G., 1977, cGMP stimulation of stem cell proliferation, Blood 49:585.PubMedGoogle Scholar
  16. Rothstein, G., Clarkson, D., Larsen, W., Grosser, B., and Athens, J., 1978, Effect of lithium on neutrophil mass and production, New Eng. J. Med. 298:178.PubMedCrossRefGoogle Scholar
  17. Singer, I., and Rotenberg, D., 1973, Mechanisms of lithium action, New Eng. J. Med. 289:254.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Peter L. Greenberg
    • 1
  • Beverly Packard
    • 1
  • Susan M. Steed
    • 1
  1. 1.Department of MedicineVeterans Administration Hospital and Stanford Medical CenterPalo AltoUSA

Personalised recommendations