Effect of Lithium on Colony Formation and Production of Colony-Stimulating Factor
Lithium is a unique and simple agent which has depressant effects on a wide variety of synthetic processes in different organs (Singer and Rotenberg, 1973), and yet has a stimulatory effect on granulopoiesis (Murphy et al., 1971; Tisman et al., 1973; Gupta et al., 1976). Its potential as a therapeutic agent in Felty’s syndrome is now well known, and future uses remain to be clearly defined. Lithium has been reported to stimulate production of colony-stimulating factor (CSF), a putative regulator of granulopoiesis (Gupta et al., 1976; Harker et al., 1977). Lithium has also been reported to enhance the action of CSF (Morley and Galbraith, 1978).
KeywordsColony Formation Aggregate Size Mononuclear Leukocyte Normal Human Bone Marrow Citrate Phosphate Dextrose
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