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The Effect of Lithium Upon Granulocyte Production in vitro and in vivo in the Mouse

  • G. Rothstein
  • A. K. Oshita
  • W. G. Harker
  • G. Lonngi
  • R. D. Christensen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Abstract

Following the institution of lithium therapy in the management of manic states, observers noted that leukocytosis and neutrophilia frequently occurred (Risetto and Gassano, 1952; Mayfield and Brown, 1966; O’Connell, 1970; Murphy and Goodwin, 1971; Shopsin and Friedman, 1971). In 1973, Tisman et al. postulated that the neutrophilia was due to an increase in the total blood granulocyte pool and also demonstrated augmentation of granulocyte proliferation in vitro (Tisman et al., 1973). In 1975, it was demonstrated that lithium enhanced colony stimulating activity (CSA) production in mice (Harker et al., 1975), and humans (Joyce and Chervenick, 1975), suggesting that this CSA alteration had a mechanistic role in vivo. In the present study, we have examined the action of lithium upon murine granulocytopoiesis in vivo and in vitro in order to: 1) further define the action of lithium upon CSA production by lung, adherent peritoneal cells, and marrow; 2) to examine the direct effect of lithium upon the proliferation of colony forming cells (CFC) or their progeny; and 3) to test the hypothesis that lithium stimulation of CSA production is due to modulation of cellular cyclic AMP (cAMP) levels.

Keywords

Peritoneal Cell Nephrogenic Diabetes Insipidus Colony Form Cell Howard Hughes Medical Institute Colony Stimulate Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • G. Rothstein
    • 1
  • A. K. Oshita
    • 1
  • W. G. Harker
    • 1
  • G. Lonngi
    • 1
  • R. D. Christensen
    • 1
  1. 1.Howard Hughes Medical Institute Laboratories Department of MedicineUniversity of UtahSalt Lake CityUSA

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