Anti-Suppressor Cell Effects of Lithium in vitro and in vivo

  • Hans-Michael Dosch
  • David Matheson
  • Ruud K. B. Schuurman
  • Erwin W. Gelfand
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)


Studies of cellular immunity nave recently begun to unravel a highly complex network of regulatory events in which a particular effector function is shown to represent the net result of multiple cell interactions which are modulated by antigenic experience, genetic restrictions, polyclonal effects, and, probably, nutritional and hormonal factors. Because of its complexity and ability to accomodate external and internal stimuli in an adaptive learning fashion, the immune network has been compared to the central nervous system (Jerne, 1974).


Peripheral Blood Lymphocyte Suppressor Cell Common Variable Immunodeficiency Antibody Deficiency Plaque Form Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cook, R.G., Stavitsky, A.B., Schoenberg, M.D., 1975, Regulation of the in vitro early anamnestic antibody response by exogenous cholera enterotoxin and cyclic AMP, J. Immunol. 114:426.PubMedGoogle Scholar
  2. Dosch, H-M. and Gelfand, E.W., 1977, Generation of human plaque-forming cells in culture: tissue distribution, antigenic and cellular requirements, J. Immunol. 118:302.Google Scholar
  3. Dosch, H-M. and Gelfand, E.W., 1978, Functional differentiation of B-lymphocytes in agammaglobulinemia. III. Characterization of spontaneous suppressor cell activity, J. Immunol. 121:2097.PubMedGoogle Scholar
  4. Dosch, H-M. and Gelfand, E.W., 1979a, Specific in vitro IgM response of human B-cells: A complex regulatory network modulated by antigen, Immunol. Rev. 45:242.CrossRefGoogle Scholar
  5. Dosch, H-M. and Gelfand, E.W., 1979b, Antigen-induced regulation of the PFC response in man, inIn vitro Induction and Measurements of Antibody Synthesis in Man” (A.S. Fauci, R.E. Ballieux, eds.), pp. 121, Academic Press, New York.Google Scholar
  6. Dosch, H-M., Percy, M.E., and Gelfand, E.W., 1977, Functional differentiation of B-lymphocytes in congenital agammaglobulinemia. I. Generation of hemolytic plaque forming cells, J. Immunol. 119:1959.PubMedGoogle Scholar
  7. Dosch, H-M., Shore, A., and Gelfand, E.W., 1979, Regulation of the specific PFC-response in man: Restraint of B-cell responsiveness, Eur. J. Immunol., in press.Google Scholar
  8. Gelfand, E.W., Biggar, W.D., and Orange, R.P., 1974, Immunological deficiency: Evaluation, diagnosis and therapy, Ped. Clin. N. Amer. 21:745.Google Scholar
  9. Gelfand, E.W., Cheung, R., Hastings, D., and Dosch, H-M., 1979a, Characterization of lithium effects on two aspects of T-cell function, (This volume).Google Scholar
  10. Gelfand, E.W. and Dosch, H-M., 1979, In vitro function heterogeneity of cellular and humoral immune deficiency states, inIn vitro Induction and Measurements of Antibody Synthesis in Man” (A.S. Fauci, R.E. Ballieux, eds.), pp 309, Academic Press, New York.Google Scholar
  11. Gelfand, E.W., Lee, J.J.W., and Dosch, H-M., 1979b, Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function, Proc. Natl. Acad. Sci. USA, 76:1998.PubMedCrossRefGoogle Scholar
  12. Gelfand, E.W., Dosch, H-M., Hastings, D., and Shore, A., 1979c, Lithium: A modulator of cyclic AMP-dependent events in lymphocytes?, Science 203:365.PubMedCrossRefGoogle Scholar
  13. Jerne, N.K., 1974, Towards a network theory of the immune system, Ann. Immunol. 125c:373.Google Scholar
  14. Limatibul, S., Shore, A.H., Dosch, H-M, and Gelfand, E.W., 1978, Theophylline modulation of E-rosette formation: An indicator of T-cell maturation, Clin. Exp. Immunol. 33:503.PubMedGoogle Scholar
  15. Schuurman, R.K.B., Gelfand, E.W., Matheson, D., Zimmerman, B., and Dosch, H-M., 1979a, Identification of Ia on a subpopulation of human T-lymphocytes which stimulate in a mixed lymphocyte reaction, J. Immunol. Submitted.Google Scholar
  16. Schuurman, R.K.B., Dosch, H-M., and Gelfand, E.W., 1979b, Polyclonal activation of human lymphocytes in vitro. I. Characterization of a B-cell mitogen in normals and immunodeficient patients, J. Immunol, Submitted.Google Scholar
  17. Shore, A., Dosch, H-M., and Gelfand, E.W., 1978, Induction and separation of antigen-dependent T-helper and T-suppressor cells in man, Nature 274:586.PubMedCrossRefGoogle Scholar
  18. Teh, H-S. and Paetkau, V., 1974, Biphasic effect of cyclic AMP on an immune response, Nature 250:505.PubMedCrossRefGoogle Scholar
  19. Waldmann, A., Broder, S., Blaese, R.M., Durm, M., Goldman, C., and Muul, L., 1979, The role of suppressor cells in human disease, in “The Biological Basis for Immunodeficiency Disease” (E.W. Gelfand, H-M. Dosch, eds.), In press, Raven Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Hans-Michael Dosch
    • 1
  • David Matheson
    • 1
  • Ruud K. B. Schuurman
    • 1
  • Erwin W. Gelfand
    • 1
  1. 1.Division of Immunology Research InstituteHospital for Sick ChildrenTorontoCanada

Personalised recommendations