Adjuvant-Like Effects of Lithium on Peripheral Blood Mononuclear Cells
Cyclic nucleotides appear to play a dynamic role in the modulation of immune responses. While an increase in lymphocyte cyclic-AMP (C-AMP) is required for the initiation of lymphocyte proliferation, a sustained elevation of cellular C-AMP levels results in a net inhibition of lymphocyte proliferation (Wang et al., 1978). Similarly, macrophage function is depressed in the presence of agents that increase cellular C-AMP (Schultz, 1978).
KeywordsLymphocyte Proliferation Latex Particle Thymidine Incorporation Suppressor Cell Human Peripheral Blood Mononuclear Cell
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