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Effect of Lithium on Acute Myelocytic Leukemia Cells in Tissue Culture — a Preliminary Study

  • J. Rosenstock
  • J. Archer
  • E. Pequignot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Abstract

Lithium was observed to increase the number of peripheral neutro-phils in hematologically normal individuals (Shopsin et al., 1971; Bille et al., 1975) and in several primary neutropenic conditions (Tisman and Show-Jen, 1977; Barrett, et al., 1977). When this effect is analysed in people receiving lithium for psychiatric reasons, it appeared to involve predominantly the myeloid cell line, though platelet counts were also increased (Bille et al., 1975). Lithium apparently causes increased neutrophil production by increasing colony stimulating activity (Turner et al., 1978).

Keywords

K562 Cell Chronic Myelogenous Leukemia Acute MYELOCYTIC Leukemia Cell Lithium Chloride Philadelphia Chromosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. Rosenstock
    • 1
  • J. Archer
    • 1
  • E. Pequignot
    • 1
  1. 1.Hahnemann Medical College and HospitalPhiladelphiaUSA

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