Effect of Lithium on Acute Myelocytic Leukemia Cells in Tissue Culture — a Preliminary Study
Lithium was observed to increase the number of peripheral neutro-phils in hematologically normal individuals (Shopsin et al., 1971; Bille et al., 1975) and in several primary neutropenic conditions (Tisman and Show-Jen, 1977; Barrett, et al., 1977). When this effect is analysed in people receiving lithium for psychiatric reasons, it appeared to involve predominantly the myeloid cell line, though platelet counts were also increased (Bille et al., 1975). Lithium apparently causes increased neutrophil production by increasing colony stimulating activity (Turner et al., 1978).
KeywordsK562 Cell Chronic Myelogenous Leukemia Acute MYELOCYTIC Leukemia Cell Lithium Chloride Philadelphia Chromosome
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