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Effects of Lithium on Neutrophil Metabolism in vitro and on Neutrophil Function During Therapy

  • J. N. Siegel
  • R. B. JohnstonJr.
  • R. S. Lowe
  • P. S. Epstein
  • A. H. Rossof
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Abstract

Lithium carbonate (LC), an effective therapeutic agent for manic depressive psychosis, induces neutrophilia associated with an increased blood neutrophil pool and survival in vivo (Rothstein et al., 1978) and with enhanced growth of granulocyte committed stem cells in vitro (Rossof and Fehir, 1979). Despite these well documented effects on the granulocyte population, few studies have investigated the interactions of lithium and granulocyte function. Reports of lithium effects on the metabolic function of a variety of relatively homogeneous cell populations have shown that lithium increases the adhesion of nervous system cells and interferes with the effects of colcemid in vitro (Reiser et al., 1975), increases the intensity of platelet aggregation and prolongs the duration of disaggregation in vitro (Imandt et al., 1977), inhibits mitogen-induced lymphocyte proliferation and suppressor T-cell activity in vitro (Gelfand et al., 1979) and enhances neutrophil skin window migration in vivo (Rothstein et al., 1978).

Keywords

Chronic Granulomatous Disease Lithium Therapy Phagocytic Index Lysosomal Enzyme Release Dextran Sedimentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Babior, B.M., Kipnes, R.S., and Curnette, J.T., 1973, The production by leukocytes of Superoxide, a potential agent, J. Clin. Invest. 52:741.PubMedCrossRefGoogle Scholar
  2. Barrett, A.J., Griscelli, C., Buriot, D., and Faille, A., 1977, Lithium therapy in congenital neutropenia. The Lancet 2:1357.CrossRefGoogle Scholar
  3. Berg, B. and Brandt, L., 1973, Syndrome of anemia, thrombocytopenia and subnormal granulocyte function in elderly patients, Scand. J. Haematol. 10:161.PubMedCrossRefGoogle Scholar
  4. Bille, P.E., Jensen, J.P.K., and Paulsen, J.C., 1975, Studies on the hematologic and cytogenic effect of lithium, Acta Med. Scand. 198:281.PubMedCrossRefGoogle Scholar
  5. Blum, S.F., 1979, Lithium therapy of aplastic anemia, New Eng. J. Med. 300:677.PubMedCrossRefGoogle Scholar
  6. Boyum, A, 1968, Isolation of mononuclear cells and granulocytes from human blood IV. Isolation of mononuclear cells by one centrifugation, Scand. J. Clin. Lab. Invest. 21:77 (Supplement).CrossRefGoogle Scholar
  7. Brittinger, G., Hirschorn, R., Douglas, S.D., and Weissman, G., 1968, Studies on lysosomes XI. Characterization of a hydrolase-rich fraction from human leukocytes, J. Cell Biol. 37:394.PubMedCrossRefGoogle Scholar
  8. Carmody, J.J. and Gage, P.W., 1973, Lithium stimulates secretion of acetylcholine in the absence of extracellular calcium, Brain Res. 50:476.PubMedCrossRefGoogle Scholar
  9. Charron, D., Barrett, A.J., Faille, A., Alby, N., Schmitt, T., and Degos, L., 1977, Lithium in acute myeloid leukemia, The Lancet 1:1307.CrossRefGoogle Scholar
  10. Craddock, P.R., White, J.G., and Jacob, H.S., 1978, Potentiation of complement (C5a)-induced granulocyte aggregation by cytochalasin B, J. Lab. Clin. Med. 91:490.PubMedGoogle Scholar
  11. Gelfand, E.W., Dosche, H-M., and Hastings, D., 1979, Lithium: A modulator of cyclic AMP-dependent events in lymphocytes, Science 203:365.PubMedCrossRefGoogle Scholar
  12. Greco, F.A. and Brereton, H.D., 1977, Effect of lithium carbonate on the neutropenia caused by chemotherapy: A preliminary clinical trial, Oncology 34:153.PubMedCrossRefGoogle Scholar
  13. Gupta, R.C., Robinson, W.A., and Kurnick, J.E., 1976, Felty’s syndrome — effect of lithium on granulopoiesis, Amer. J. Med. 61:29.PubMedCrossRefGoogle Scholar
  14. Henson, P.M., 1971, The immunologic release of constituents from neutrophil leukocytes I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles, J. Immunol. 107:1535.PubMedGoogle Scholar
  15. Holland, J.F., Senn, H., and Banerjee, T., 1971, Quantitative studies of localized leukocyte mobilization in acute leukemia, Blood 37:499.PubMedGoogle Scholar
  16. Imandt, L., Genders, T., Wessels, H., and Haanen, C., 1977, The effect of lithium on platelet aggregation and platelet release reaction, Thromb. Res. 11:297.PubMedCrossRefGoogle Scholar
  17. Johnston, R.B., Jr., Keele, B.B., Jr., Misra, H.P., Lehmeyer, J.E., Webb, L.S., Baehner, R.L., and Rajagopalan, K.V., 1975, The role of Superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes, J. Clin. Invest. 55:1357.PubMedCrossRefGoogle Scholar
  18. Lehrer, R.I. and Cline, M.J., 1969, Interaction of Candida albicans with human leukocytes and serum, J. Bacteriol. 98:996.PubMedGoogle Scholar
  19. Lyman, G.H., Williams, C.C., and Preston, D., 1978, A prospective randomized study of the effect of lithium carbonate on the granulocyto-penia and incidence of infection associated with intensive chemotherapy and radiation therapy for undifferentiated small cell bronchogenic carcinoma, Blood 52:228 (Supplement 1).Google Scholar
  20. Mayfield, D. and Brown, R.G., 1966, The clinical laboratory and electroen-ephalographic effects of lithium, J. Psychiat. Res. 4:207.PubMedCrossRefGoogle Scholar
  21. Mellerup, E.T. and Jorgensen, O.S., 1975, Basic chemistry and biological effects of lithium, in: “Lithium Research and Therapy,” (F.N. Johnson, ed.) p. 353, Academic Press Inc.Google Scholar
  22. Perez, H.D., Kaplan, H., Shenkman, L., Borkowsky, W., and Goldstein, I.M., 1979, Reversal of an abnormality of polymorphonuclear leukocyte chemo-taxis with lithium, Clin. Res. 27:353A.Google Scholar
  23. Rampon, S., Bussiere, J-L., Sauvezie, B., Missioux, D., Lopitaux, R., and Prive, L., 1976, Traitement du syndrome de Felty par le lithium, La Nouvelle Presse Medicale 5:1756.Google Scholar
  24. Reiser, G., Lautenschlager, E., and Hamprecht, B., 1975, Effects of colemid and lithium ions on processes of cultured cells derived from the nervous system, in: “Microtubules and Microtubule Inhibitors,” (M. Borgers and M. de Brabander, eds.) North-Holland Publishing Company, Amsterdam.Google Scholar
  25. Rossof, A.H. and Fehir, K.M., 1979, Lithium carbonate increases marrow granulocyte-committed colony-forming units and peripheral blood granulocytes in a canine model, Exp. Hematol. 7:255.PubMedGoogle Scholar
  26. Rothstein, G., Clarkson, D.R., Larsen, W., Grosser, B.I., and Athens, J.W., 1978, Effect of lithium on neutrophil mass and production, New Eng. J. Med. 298:178.PubMedCrossRefGoogle Scholar
  27. Schapira, D.V., Gordon, P.A., and Herbert, F.A., 1977, Reduction of infections is Felty’s sydrome through use of lithium, Arth. Rheum. 28:1556.CrossRefGoogle Scholar
  28. Shopsin, B., Friedmann, R., and Gershon, S., 1971, Lithium and leukocytosis, Clin. Pharmacol. Ther. 12:923.PubMedGoogle Scholar
  29. Singer, I. and Rotenberg, D., 1973, Mechanisms of lithium action, New Eng. J. Med. 189:254.CrossRefGoogle Scholar
  30. Smolelis, A.N. and Hartseil, S.E., 1949, The determination of lysozyme, J. Bacteriol. 58:731.PubMedGoogle Scholar
  31. Stein, R.S., Beaman, C., Ali, M.Y., Hansen, R., Jenkins, D.D., and Jume’an, H.G., 1977, Lithium carbonate attenuation of chemotherapy-induced neutropenia, New Eng. J. Med. 297:430.PubMedCrossRefGoogle Scholar
  32. Stein, R.S., Flexner, J.M., and Graber, S., 1978, Lithium and granulocytopenia during induction therapy of acute myelogenous leukemia, Blood 52:277 (Supplement 1).Google Scholar
  33. Stjernholm, R.L. and Manak, R.C., 1970, Carbohydrate metabolism in leukocytes XIV. Regulation of pentose cycle activity and glycogen metabolism during phagocytosis, J. Reticuloendothel. Soc. 8:550.PubMedGoogle Scholar
  34. Tisman, G., Herbert, V., and Rosenblatt, S., 1973, Evidence that lithium induces vitamin B12-binding capacity in vivo and granulocyte colony proliferation in vitro, Br. J. Haematol. 24:767.PubMedCrossRefGoogle Scholar
  35. Tisman, G., 1974, Lithium carbonate protection against drug-induced leukopenia in lymphosarcoma patients, IRCS 2:1509.Google Scholar
  36. Turner, A.R., MacDonald, R.N., and McPherson, T.A., 1979, Reduction of chemotherapy-induced neutropenic complications with a short course of lithium carbonate, Clin. Invest. Med. in press.Google Scholar
  37. Visca, U., Mensi, F., Spina, M.P., Bombara, R., Giraldi, B., Massari, A., Rossi, F., and Santi, G., 1979, Prevention of antiblastic neutropenia with lithium carbonate, The Lancet 1:779.CrossRefGoogle Scholar
  38. Wang, Y.C., Pandey, G.N., Mendels, J., and Frazer, A., 1974, Effect of lithium on prostaglandin El-stimulated adenylate cyclase activity of human platelets, Biochem. Pharmacol. 23:845.PubMedCrossRefGoogle Scholar
  39. Wroblewski, F. and LaDue, J.S., 1953, Lactic dehydrogenase activity in blood, Proc. Soc. Exp. Biol. Med. 90:210.Google Scholar
  40. Zurier, R.B., Hoffstein, S., and Weissman, G., 1973, Lysosomal enzyme release from human leukocytes I. Effect of cyclic nucleotides and colchicine, J. Cell Biol. 58:27.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. N. Siegel
    • 1
    • 2
    • 3
  • R. B. JohnstonJr.
    • 1
    • 2
    • 3
  • R. S. Lowe
    • 1
    • 2
    • 3
  • P. S. Epstein
    • 1
    • 2
    • 3
  • A. H. Rossof
    • 1
    • 2
    • 3
  1. 1.Rush-Presbyterian-St. Luke’s Medical CenterChicagoUSA
  2. 2.National Jewish Hospital and Research CenterDenverUSA
  3. 3.Wilford Hall USAF Medical CenterSan AntonioUSA

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