Effects of Lithium on Neutrophil Metabolism in vitro and on Neutrophil Function During Therapy
Lithium carbonate (LC), an effective therapeutic agent for manic depressive psychosis, induces neutrophilia associated with an increased blood neutrophil pool and survival in vivo (Rothstein et al., 1978) and with enhanced growth of granulocyte committed stem cells in vitro (Rossof and Fehir, 1979). Despite these well documented effects on the granulocyte population, few studies have investigated the interactions of lithium and granulocyte function. Reports of lithium effects on the metabolic function of a variety of relatively homogeneous cell populations have shown that lithium increases the adhesion of nervous system cells and interferes with the effects of colcemid in vitro (Reiser et al., 1975), increases the intensity of platelet aggregation and prolongs the duration of disaggregation in vitro (Imandt et al., 1977), inhibits mitogen-induced lymphocyte proliferation and suppressor T-cell activity in vitro (Gelfand et al., 1979) and enhances neutrophil skin window migration in vivo (Rothstein et al., 1978).
KeywordsChronic Granulomatous Disease Lithium Therapy Phagocytic Index Lysosomal Enzyme Release Dextran Sedimentation
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- Johnston, R.B., Jr., Keele, B.B., Jr., Misra, H.P., Lehmeyer, J.E., Webb, L.S., Baehner, R.L., and Rajagopalan, K.V., 1975, The role of Superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes, J. Clin. Invest. 55:1357.PubMedCrossRefGoogle Scholar
- Lyman, G.H., Williams, C.C., and Preston, D., 1978, A prospective randomized study of the effect of lithium carbonate on the granulocyto-penia and incidence of infection associated with intensive chemotherapy and radiation therapy for undifferentiated small cell bronchogenic carcinoma, Blood 52:228 (Supplement 1).Google Scholar
- Mellerup, E.T. and Jorgensen, O.S., 1975, Basic chemistry and biological effects of lithium, in: “Lithium Research and Therapy,” (F.N. Johnson, ed.) p. 353, Academic Press Inc.Google Scholar
- Perez, H.D., Kaplan, H., Shenkman, L., Borkowsky, W., and Goldstein, I.M., 1979, Reversal of an abnormality of polymorphonuclear leukocyte chemo-taxis with lithium, Clin. Res. 27:353A.Google Scholar
- Rampon, S., Bussiere, J-L., Sauvezie, B., Missioux, D., Lopitaux, R., and Prive, L., 1976, Traitement du syndrome de Felty par le lithium, La Nouvelle Presse Medicale 5:1756.Google Scholar
- Reiser, G., Lautenschlager, E., and Hamprecht, B., 1975, Effects of colemid and lithium ions on processes of cultured cells derived from the nervous system, in: “Microtubules and Microtubule Inhibitors,” (M. Borgers and M. de Brabander, eds.) North-Holland Publishing Company, Amsterdam.Google Scholar
- Stein, R.S., Flexner, J.M., and Graber, S., 1978, Lithium and granulocytopenia during induction therapy of acute myelogenous leukemia, Blood 52:277 (Supplement 1).Google Scholar
- Tisman, G., 1974, Lithium carbonate protection against drug-induced leukopenia in lymphosarcoma patients, IRCS 2:1509.Google Scholar
- Turner, A.R., MacDonald, R.N., and McPherson, T.A., 1979, Reduction of chemotherapy-induced neutropenic complications with a short course of lithium carbonate, Clin. Invest. Med. in press.Google Scholar
- Wroblewski, F. and LaDue, J.S., 1953, Lactic dehydrogenase activity in blood, Proc. Soc. Exp. Biol. Med. 90:210.Google Scholar