Granulocyte Function in Patients Receiving Lithium Carbonate
Phagocytic cells provide protection against a wide variety of microbial pathogens. A depletion of polymorphonuclear leukocytes (PMNs) below a critical number (Bodey et al., 1966) and/or abnormality in their cellular function (Quie, 1975) is associated with serious infection. Therefore, agents capable of enhancing phagocyte number and function are of importance. The lithium ion (Li+) induces leukocytosis (Shopsin et al., 1971) and may diminish the neutropenia associated with cancer chemotherapy (Greco and Brereton, 1977; Charron et al., 1977; Stein et al., 1977). While such effects appear desirable, it is equally important that the functions of these phagocytic cells are preserved in their contribution to the host defense system. In this paper we shall report our investigation into the microbicidal ability of neutrophils obtained from patients receiving lithium carbonate (Li2CO3), and the in vitro effects of lithium chloride (LiCl) on several PMN functions.
KeywordsAcute Myeloid Leukemia Polymorphonuclear Leukocyte Phagocytic Activity Patient Seron Lithium Chloride
Unable to display preview. Download preview PDF.
- Bodey, G.P., Buckley, M., Sathe, Y.S., and Freireich, E.J., 1966, Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia, Ann, Intern, Med. 64:328.Google Scholar
- MacGregor, R.R. and Dyson, W.L., 1978, Effect of lithium on granulocyte adherence, Clin. Res. 26:352A.Google Scholar
- Marchesi, J.T. and Florey, H.W., 1960, Electron micrographic observations on the emigration of leukocytes, Quart. Journ. Expt. Physio. 45:343.Google Scholar
- Perez, H.D., Kaplan, H., Shenkman, L., Borkowsky, W., and Goldstein, I.M., 1979, Reversal of an abnormality of polymorphonuclear leukocyte chemo-taxis with lithium, Clin. Res. 27:353A.Google Scholar
- Shopsin, B., Friedman, R., and Gershon, S., 1971, Lithium and leukocytosis, Clin. Pharmcol. Ther. 12:923.Google Scholar
- Stein, R.S., Hansen, G.H., Koethe, S., and Hansen, R., 1978, Lithium induced granulocytosis, Ann. Intern. Med. 88:1978.Google Scholar