In vivo and in vitro Effects of Lithium on Granulopoiesis in Human Neutropenic Disorders
Administration of lithium salts to humans increases peripheral blood neutrophil counts (O’Connell, 1970; Shopsin et al., 1971). It has been shown that this is due to a true increase in neutrophil mass, rather than a shift in peripheral blood neutrophil pools (Tisman et al., 1973; Rothstein et al., 1978). The mechanism of action of lithium in this regard has been studied by a number of investigators using in vitro techniques (Joyce and Chervenick, 1975; Harker et al., 1977; Morley and Galbraith, 1978; Spitzer et al., in press). It has been shown that lithium leads to increased production of the granulocyte colony stimulating factor (CSF) by adherent peripheral blood and bone marrow cells. CSF is the presumed humoral regulator of granulocyte production and has been partially characterized as a glycoprotein with a molecular weight of approximately 35,000 daltons (Robinson and Mangalik, 1975; Metcalf, 1977). Further, it has been shown that lithium does not alter the functional capacity of neutrophils, suggesting that it may be useful as a therapeutic agent in human neutropenic disorders (Rossof and Coltman, Jr., 1976; Cohen et al., 1979).
KeywordsArthritis Agar Lithium Attenuation Leukemia
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- Joyce, R.A. and Chervenick, P.A., 1975, Effect of lithium on the release of colony stimulating activity (CSA) from blood leukocytes, Proc. Am. Soc. Haematol. 18:126.Google Scholar
- O’Connell, R.A., 1970, Leukocytosis during lithium carbonate treatment, Int. J. Pharmacopsychiatry 4:30.Google Scholar
- Robinson, W.A., Entringer, M.A., and Otsuka, A.L., 1972, In vitro studies in acute granulocytic leukaemia in humans, in “The Nature of Leukaemia” (P.C. Vincent, ed.), pp. 151–161, V.C.N. Blight, Sydney, N.S.W., Australia.Google Scholar
- Spitzer, G., Verma, D.S., Barlogie, B., McCredie, K.G., and Dicke, K., 1979, Possible mechanisms of action involved in the augmentatioin of in vitro spontaneous myeloid colony formation by lithium, Cancer Res., in press.Google Scholar
- Tisman, G., 1974, Lithium carbonate protection against drug-induced leukopenia in lymphosarcoma patients, IRCS 2:1509.Google Scholar