Lithium and Granulocytopenia During Induction Therapy of Acute Myelogenous Leukemia: Update of an Ongoing Trial

  • Richard S. Stein
  • John H. Flexner
  • Stanley E. Graber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)


Administration of lithium carbonate to normal subjects and psychiatric patients causes increased production of granulocytes (Rothstein et al., 1978; Stein et al., 1978b). The administration of lithium carbonate to patients receiving cancer chemotherapy can attenuate neutropenia when regimens of moderate myelotoxicity are employed (Stein et al., 1977; Greco and Brereton, 1977). We have previously reported in preliminary form (Stein et al., 1978a) that lithium can limit the duration of the severe neutropenia associated with chemotherapy of acute myelogenous leukemia (AML), a situation in which effective therapy is associated with severe neutropenia. This report presents an update of that clinical trial.


Induction Therapy Acute Myelogenous Leukemia Severe Neutropenia Lithium Therapy Lithium Level 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Richard S. Stein
    • 1
  • John H. Flexner
    • 1
  • Stanley E. Graber
    • 1
  1. 1.Department of MedicineVanderbilt University School of Medicine and The Veterans Administration HospitalNashvilleUSA

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