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Lithium Carbonate Enhances Granulopoiesis and Attenuates Cyclophosphamide-Induced Injury in the Dog

  • A. H. Rossof
  • K. M. Fehir
  • H. S. Budd
  • A. Murthy
  • S. G. Economou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Abstract

When given to manic-depressive psychiatric patients, lithium carbonate (LC) is associated with an increase in the number of circulating neutrophils (PMNs) (Mayfield and Brown, 1966; O’Connell, 1970; Shopsin et al., 1971; Murphy et al., 1971, Watanabe et al., 1974; and Bille et al., 1975). This is an intriguing “side effect” which suggests several potential clinical applications: 1) prevention or attenuation of myelosuppression due to anti-cancer chemotherapy or radiotherapy; 2) treatment of neutropenic disorders not related to cancer therapy; 3) preparation of granulocyte donors prior to leucopheresis; and 4) acceleration of engraftment of bone marrow allografts or autografts. A detailed analysis of LC enhanced granulopoiesis and some prediction of its efficacy in these potential roles would be aided if a suitable animal model were available for comprehensive study. It is the purpose of this report to present our observations on lithium carbonate stimulation of marrow granulocyte-committed colony-forming units (CFU-c) and peripheral blood granulocytes in mongrel dogs and the protection offered these dogs from cyclophosphamide-induced marrow injury.

Keywords

Lithium Carbonate Lithium Carbonate Treatment Colony Stimulate Activity Peripheral Blood Granulocyte Thiamylal Sodium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bille, P.E., Jensen, J.P.K., and Poulsen, J.C., 1975, Studies on the hematologic and cytogenetic effect of lithium, Acta Med. Scand. 198:281.PubMedCrossRefGoogle Scholar
  2. Charron, D., Barrett, A.J., Faille, A., Alby, N., Schmitt, T., and Degos, L., 1977, Lithium in acute myeloid leukemia, Lancet 1:1307.PubMedCrossRefGoogle Scholar
  3. Cohen, M.S., Zakhireh, B., Metcalf, J.A., and Root, R.K., 1979, Granulocyte function during lithium therapy, Blood 53:913.PubMedGoogle Scholar
  4. Greco, F.A. and Brereton, H.D., 1977, Effect of lithium carbonate on the neutropenia caused by chemotherapy: a preliminary clinical trial, Oncology 34:153.PubMedCrossRefGoogle Scholar
  5. Greco, F.A., 1978, Personal communication.Google Scholar
  6. Gupta, R.C., Robinson, W.A., and Kurnick, J.E., 1976, Felty’s syndrome: effect of lithium on granulopoiesis, Am. J. Med. 61:29.PubMedCrossRefGoogle Scholar
  7. Harker, W.G., Rothstein, G., Clarkson, D.R., Athens, J.W., and MacFarlane, J.L., 1977, Enhancement of colony-stimulating activity production by lithium, Blood 49:263.PubMedGoogle Scholar
  8. Lyman, G.H., Williams, C.C., and Preston, D., 1978, A prospective randomized study of the effect of lithium carbonate on the granulocytopenia and incidence of infection associated with intensive chemotherapy and radiation therapy for undifferentiated small cell bron-chogenic carcinoma, Blood 52:228 (Supplement 1).Google Scholar
  9. Marsh, J.C., Levitt, M., and Katzenstein, A., 1972, The growth of leukocyte colonies in vitro from dog bone marrow, J. Lab. Clin. Med. 79:1041.PubMedGoogle Scholar
  10. Mayfield, D. and Brown, R.G., 1966, The clinical laboratory and electro-encephalographic effects of lithium, J. Psychiat. Res. 4:207.PubMedCrossRefGoogle Scholar
  11. Murphy, D.L., Goodwin, F.K., and Bunney, W.E., Jr., 1971, Leukocytosis during lithium treatment, Amer. J. Psychiat. 127:1559.PubMedGoogle Scholar
  12. O’Connell, R.A., 1970, Leukocytosis during lithium carbonate treatment, Int. Pharmacopsychiat. 4:30.Google Scholar
  13. Robinson, W.A. and Mangalik, A., 1975, The kinetics and regulation of granulopoiesis, Sem. Hematol. 12:7.Google Scholar
  14. Rossof, A.H., 1975, Unpublished observations.Google Scholar
  15. Rossof, A.H. and Coltman, C.A., Jr., 1976, The effect of lithium carbonate on the granulocyte phagocytic index, Experientia 32:238.PubMedCrossRefGoogle Scholar
  16. Rossof, A.H. and Fehir, K.M., 1978, Lithium stimulation of granulopoiesis, New Eng. J. Med. 298:280.PubMedGoogle Scholar
  17. Rothstein, G., Clarkson, D.R., Larsen, W., Grosser, B.I., and Athens, J.W., 1978, Effect of lithium on neutrophil mass and production, New Eng. J. Med. 298:178.PubMedCrossRefGoogle Scholar
  18. Ruscetti, F.W. and Chervenick, P.A., 1975, Release of colony stimulating activity from thymus-derived lymphocytes, J. Clin. Inves. 55:520.CrossRefGoogle Scholar
  19. Shively, J.N., Michaelson, S.M., and Howland, J.W., 1958, The response of dogs to bilateral whole body Co60 irradiation, Rad. Res. 9:445.CrossRefGoogle Scholar
  20. Shopsin, B., Friedman, R., and Gershon, S., 1971, Lithium and leukocytosis, Clin. Pharm. Ther. 12:923.Google Scholar
  21. Siegel, J., Johnston, R.B., Jr., Lowe, R.S., Epstein, P.S., and Rossof, A.H., 1980, Effects of lithium on neutrophil metabolism in vitro and on neutrophil function during therapy, (This volume).Google Scholar
  22. Siegel, S., 1956, “Non-Parametric Statistics for the Behavioral Sciences,” McGraw-Hill, New York.Google Scholar
  23. Stein, R.S., Beaman, C, Ali, M.Y., Hansen, R., Jenkins, D.D., and Jume’an, H.G., 1977, Lithium carbonate attenuation of chemotherapy-induced neutropenia, New Eng. J. Med. 297:430.PubMedCrossRefGoogle Scholar
  24. Stein, R.S., Flexner, J.M., and Graber, S., 1978, Lithium and granulocy-topenia during induction therapy of acute myelogenous leukemia, Blood 52:277 (Supplement 1).Google Scholar
  25. Tisman, G., Herbert, V., and Rosenblatt, S., 1973, Evidence that lithium induces human granulocyte proliferation: elevated serum vitamin B12 binding capacity in vivo and granulocyte proliferation in vitro, Br. J. Haematol. 24:767.PubMedCrossRefGoogle Scholar
  26. Tisman, G., 1974, Lithium carbonate protection against drug-induced leukopenia in lymphosarcoma patients, IRCS 2:1509.Google Scholar
  27. Turner, A.R., MacDonald, R.N., and McPherson, T.A., 1979, Reduction of chemotherapy-induced neutropenic complications with a short course of lithium carbonate, Clin. Invest. Med., in press.Google Scholar
  28. Visca, U., Mensi, F., Spina, M.P., Bombara, R., Giraldi, B., Massari, A., Rossi, F., and Santi, G., 1979, Prevention of antiblastic neutropenia with lithium carbonate, Lancet 1:779.PubMedCrossRefGoogle Scholar
  29. Watanabe, S., Taguchi, K., Nakashima, Y., Ebara, T., Iguchi, K., and Otsuki, S., 1974, Leukocytosis during lithium treatment and its correlation to serum lithium level, Folia Psych. Neurol. Japonica 28:161.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • A. H. Rossof
    • 1
  • K. M. Fehir
    • 1
  • H. S. Budd
    • 1
  • A. Murthy
    • 1
  • S. G. Economou
    • 1
  1. 1.Departments of Medicine, Therapeutic Radiology, and General SurgeryRush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

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