Lithium Carbonate Enhances Granulopoiesis and Attenuates Cyclophosphamide-Induced Injury in the Dog
When given to manic-depressive psychiatric patients, lithium carbonate (LC) is associated with an increase in the number of circulating neutrophils (PMNs) (Mayfield and Brown, 1966; O’Connell, 1970; Shopsin et al., 1971; Murphy et al., 1971, Watanabe et al., 1974; and Bille et al., 1975). This is an intriguing “side effect” which suggests several potential clinical applications: 1) prevention or attenuation of myelosuppression due to anti-cancer chemotherapy or radiotherapy; 2) treatment of neutropenic disorders not related to cancer therapy; 3) preparation of granulocyte donors prior to leucopheresis; and 4) acceleration of engraftment of bone marrow allografts or autografts. A detailed analysis of LC enhanced granulopoiesis and some prediction of its efficacy in these potential roles would be aided if a suitable animal model were available for comprehensive study. It is the purpose of this report to present our observations on lithium carbonate stimulation of marrow granulocyte-committed colony-forming units (CFU-c) and peripheral blood granulocytes in mongrel dogs and the protection offered these dogs from cyclophosphamide-induced marrow injury.
KeywordsLithium Carbonate Lithium Carbonate Treatment Colony Stimulate Activity Peripheral Blood Granulocyte Thiamylal Sodium
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