Lithium Effects on Granulopoiesis in Mice Following Cytotoxic Chemotherapy
Recent clinical studies have suggested that administration of lithium may modify the duration of neutropenia in patients receiving chemotherapy for treatment of acute leukemia (Stein et al., 1978) and solid tumors (Stein et al., 1977; Lyman et al., 1978). Fehir and Rossof (1978) reported similar effects of lithium in dogs following administration of cyclophosphamide. The mechanisms by which lithium increases blood neutrophil concentrations are not completely understood. Neutrophilia is associated with increased marrow neutrophil production (Malloy et al., 1978; Rothstein et al., 1978), increased neutrophil progenitor cells (CFU-C) (Tisman et al., 1973; Joyce and Chervenick, 1979) and enhanced release of colony stimulating activity (CSA) (Joyce and Chervenick, 1975; Harker et al., 1977). The present studies describe changes in hematopoiesis during daily administration of lithium chloride (Li) to normal mice and report enhanced recovery of granulopoiesis following administration of cytotoxic drugs.
KeywordsCytotoxic Chemotherapy Lithium Chloride Colony Stimulate Activity Bone Marrow Neutrophil Pluripotent Hematopoietic Stem Cell
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