The Role of Immune Mechanisms in Pathogenesis

  • Sally Ann Huber
Part of the Infectious Agents and Pathogenesis book series (IAPA)


Although most coxsackievirus (CV) infections in humans are mild and frequently asymptomatic, in some individuals more serious manifestations develop, including meningitis, paralysis, encephalitis, type I (insulin-dependent) diabetes mellitus (IDDM), and myocarditis.1–3 Association of particular viral infections with certain diseases usually depends on demonstration of rising antibody titers to the pathogen and a compatible clinical history. In both IDDM and myocarditis, approximately 50% of recently diagnosed patients demonstrate two- to fourfold rises in CV-specific antibodies compared with less than 20% of control patients.2,3 Furthermore, several studies report dramatic increases in new diabetes and myocarditis cases coinciding with known CV epidemics and also demonstrate definite seasonality for these diseases (fall and winter) that correlate remarkably well with the seasonal distribution of Picornavirus infections.2,3 Despite the nearly convincing circumstantial evidence of CV etiology in myocarditis and diabetes, infectious virus is only rarely isolated from patients with active disease.3


Major Histocompatibility Complex Major Histocompatibility Complex Antigen Peripheral Lymphoid Organ Induce Diabetes Mellitus Immunopathogenic Mechanism 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Sally Ann Huber
    • 1
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA

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