Perspectives on Cellular Receptors as Determinants of Viral Tropism

  • Richard L. Crowell
  • Burton J. Landau
  • Kuo-Hom Lee Hsu
  • Maggie Schultz
Part of the Infectious Agents and Pathogenesis book series (IAPA)


Coxsackievirus (CV) infections of humans were recently reviewed1 and are also discussed elsewhere in this volume. These agents cause a wide variety of syndromes, including meningitis, pleurodynia, myositis, herpangina, myocarditis, pericarditis, pancreatitis, hepatitis, nephritis, orchitis, gastroenteritis, exanthems, acute respiratory disease, and congenitally acquired disease. In addition, inapparent or mild infections may be common and provide a source of virus to help explain the ubiquitous spread of infections. No conclusive evidence is available to explain why some individuals develop acute self-limiting infections, while others develop a severe or chronic disease. Nevertheless, it is predicted that cellular receptors play an important role in determining the tropism of CV in the pathogenesis of infection.


HeLa Cell Cellular Receptor Virus Attachment Human Rhinovirus Viral Tropism 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Richard L. Crowell
    • 1
  • Burton J. Landau
    • 1
  • Kuo-Hom Lee Hsu
    • 1
  • Maggie Schultz
    • 1
  1. 1.Department of Microbiology and ImmunologyHahnemann University School of MedicinePhiladelphiaUSA

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