Diabetes Mellitus

  • Antonio Toniolo
  • Giovanni Federico
  • Fulvio Basolo
  • Takashi Onodera
Part of the Infectious Agents and Pathogenesis book series (IAPA)


The term diabetes refers to a group of disorders having in common hyperglycemia and an elevated prevalence of serious complications affecting many organ systems. Studies of the natural history and pathogenesis of hyperglycemia have led to a widely accepted classification developed by the National Diabetes Data Group. Among the various diabetic syndromes that are now recognized, insulin-dependent diabetes mellitus (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) account for the great majority of cases, the former being less prevalent. It is now clear that IDDM derives from a deficiency of insulin production due to the loss of pancreatic β-cells, while NIDDM is mostly due to a reduced effect of this hormone on peripheral tissues. Because coxsackieviruses (CV), and in particular the members of group B (CVB), have been implicated only in the etiopathogenesis of IDDM, this discussion refers exclusively to this form of diabetes.


Islet Cell Viral Antigen Islet Cell Antibody Coxsackie Virus Mumps Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Antonio Toniolo
    • 1
  • Giovanni Federico
    • 2
  • Fulvio Basolo
    • 3
  • Takashi Onodera
    • 4
  1. 1.Institute of Microbiology and VirologyUniversity of Sassari Medical SchoolSassariItaly
  2. 2.Department of PediatricsUniversity of PisaPisaItaly
  3. 3.Department of PathologyUniversity of PisaPisaItaly
  4. 4.Laboratory of Viral ImmunologyNational Institute of Animal HealthTsukuba, Ibaraki 305Japan

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