A Unique Lactate Dehydrogenase Isozyme in the Teleost Retina

  • Gregory S. Whitt
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 1)


The main research of this laboratory over the past few years has focused on the developmental and biochemical genetics of fishes. One of the most interesting gene products investigated is the enzyme lactate dehydrogenase (LDH), particularly the isozyme of LDH found in the retina of many groups of teleosts (Markert and Faulhaber, 1965). This isozyme may play an important role in visual metabolism (Whitt, 1970; Whitt and Booth, 1970; Whitt et al., 1973).


Outer Segment Photoreceptor Cell Visual Pigment Visual Cycle Enzyme Lactate Dehydrogenase 
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  1. Ali, M.A. (1959). The ocular structure, retinomotor and photo-behavioural responses of juvenile Pacific salmon. Can. J. Zool. 37: 965–996.CrossRefGoogle Scholar
  2. Goldberg, E., Cuerrier, J.P. and Ward, J.C. (1969). Lactate dehydrogenase ontogeny, paternal gene activation, and tetramer assembly in embryos of brook trout, lake trout, and their hybrids. Biochem. Genet. 2: 335–350.PubMedCrossRefGoogle Scholar
  3. Hitzeroth, H., Klose, J., Ohno, S., and Wolf, U. (1968). Asynchronous activation of parental alleles at the tissue-specific gene loci observed on hybrid trout during early development. Biochem. Genet. 1: 287–300.PubMedCrossRefGoogle Scholar
  4. Kunz, Y. (1971). Distribution of lactate dehydrogenase (and its E-isozymes) in the developing and adult retina of the guppy (Lebistes reticulatus). Rev. Suisse Zool. 78: 761–776.Google Scholar
  5. Machado de Domenech, E., Domenech, C.E., Aoki, A. and Blanco, A. (1972). Association of the testicular lactate dehydrogenase isozyme with a special type of mitochondria. Biol. Reprod. 6: 136–147.Google Scholar
  6. Markert, C.L., and Faulhaber, I. (1965). Lactate dehydrogenase isozyme patterns of fish. J. Exp. Zool. 159: 319–332.PubMedCrossRefGoogle Scholar
  7. Markert, C.L. and Møller, F. (1959). Multiple forms of enzymes: Tissue, ontogenetic, and species specific patterns. Proc. Natl. Acad. Sci. U.S.A. 45: 753–763.PubMedCrossRefGoogle Scholar
  8. Miller, E.T. and Whitt, G.S. (1974). Lactate dehydrogenase isozyme synthesis and cellular differentiation in the teleost retina. In: Isozymes, Vol. 3. Edited by C.L. Markert. Academic Press. (In press).Google Scholar
  9. Nakano, E. and Whiteley, A.H. (1965). Differentiation of multiple molecular forms of four dehydrogenases in the teleost, Osyzias latipes, studied by disc electrophoresis. J. Exp. Zool. 159: 167–179.PubMedCrossRefGoogle Scholar
  10. Nakano, E. and Hasegawa, M. (1971). Differentiation of the retina and retinal lactate dehydrogenase isoenzymes in the teleost, Oryzias latipes. Dev., Growth and Diff. 13: 351–357.CrossRefGoogle Scholar
  11. Shaklee, J.B., Kepes, K.L. and Whitt, G.S. (1973). Specialized lactate dehydrogenase isozymes: The molecular and genetic basis for the unique eye and liver LDHs of teleost fishes. J. Exp. Zool. 185: 217–240.PubMedCrossRefGoogle Scholar
  12. Wald, G. (1968). Molecular basis of visual excitation. Science 162: 230–239.PubMedCrossRefGoogle Scholar
  13. Whitt, G.S. (1969). Homology of lactate dehydrogenase genes: E gene function in the teleost nervous system. Science 166: 1156–1158.PubMedCrossRefGoogle Scholar
  14. Whitt, G.S. (1970). Developmental genetics of the lactate dehydrogenase isozymes of fish. J. Exp. Zool. 175: 1–35.PubMedCrossRefGoogle Scholar
  15. Whitt, G.S. and Booth, G.M. (1970). Localization of lactate dehydrogenase activity in the cells of the fish (Xiphophorus hellevi) eye. J. Exp. Zool. 174: 215–224.PubMedCrossRefGoogle Scholar
  16. Whitt, G.S., Childers, W.F., and Wheat, T.E. (1971). The inheritance of tissue-specific lactate dehydrogenase isozymes in interspecific bass (Mievoptevus) hybrids. Biochem. Genet. 5: 257–273.PubMedCrossRefGoogle Scholar
  17. Whitt, G.S., Miller, E.T., and Shaklee, J.B. (1973). Developmental and biochemical genetics of lactate dehydrogenase isozymes in fishes, p. 243–276. In: Genetics and mutagenesis of fish Edited by J.H. Schröder. Springer-Verlag, New York, 356 pp.CrossRefGoogle Scholar
  18. Whitt, G.S., Shaklee, J.B. and Markert, C.L. (1974). Evolution of the lactate dehydrogenase isozymes of fishes. In: Isozymes Vol. 4. Edited by C.L. Markert. Academic Press. (In press).Google Scholar
  19. Wittenberg, J.B. and Wittenberg, B.A. (1974). The choroid rete mirabile of the fish eye. 1. Oxygen secretion and structure: comparison with the swimbladder rete mirabile. Biol. Bull. 145: 116–136.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Gregory S. Whitt
    • 1
  1. 1.Department of Genetics and DevelopmentUniversity of IllinoisUrbanaUSA

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