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Profilin: A Novel Pan-Allergen and Actin-Binding Protein in Plants

  • Rudolf Valenta
  • Ines Swoboda
  • Monika Grote
  • Susanne Vrtala
  • Fatima Ferreira
  • Michael Duchêne
  • Erwin Heberle-Bors
  • Dietrich Kraft
  • Otto Scheiner

Abstract

Using serum-IgE from a pollen-allergic patient we isolated a cDNA from a birch pollen expression library (Valenta et al., 1991a). The deduced amino acid sequence of this cDNA clone showed significant homology with sequences from other eukaryotic profilins. Profilins function as actin-binding proteins (Isenberg et al., 1980) and interact with phosphatidylinositol 4,5 bisphosphate (PIP2) (Goldschmidt-Clermont et al., 1990). In addition a role of profilins in the signal transduction cascade via CAP was proposed (Vojtek et al., 1991). These data indicate that profilins are essential components of eukaryotic cells. This chapter concerning the biological functions of plant profilins illustrates that these proteins are ubiquitously distributed in plants and are structurally similar. For this reason plant profilins can function as targets for cross-reactive IgE antibodies of allergic patients and represent a novel class of pan-allergens.

Keywords

Pollen Tube Acrosomal Reaction Pollen Allergen Birch Pollen Female Inflorescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman & Hall 1996

Authors and Affiliations

  • Rudolf Valenta
  • Ines Swoboda
  • Monika Grote
  • Susanne Vrtala
  • Fatima Ferreira
  • Michael Duchêne
  • Erwin Heberle-Bors
  • Dietrich Kraft
  • Otto Scheiner

There are no affiliations available

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