Characterization of a Dominant Epitope of the Major Allergens of Parietaria

  • Anna Ruffilli
  • Anna Scotto d’Ambusco
  • C. De Santo


Recently physicochemical characterization of allergens isolated from native sources has been accompanied by molecular cloning of allergen genes. Several epidemiologically and clinically relevant pollen allergens, as well as those that have been used as models for classical studies, are now being studied at the level of recombinant DNA products (Bond et al., 1991; Breiteneder et al., 1989, 1992; Perez et al., 1990; Griffith et al., 1991a; Gosh et al., 1991; Valenta et al., 1991a, 1992a; Silvanovich et al., 1991; Rafnar et al., 1991; Rogers et al., 1991; Singh et al., 1991). This approach promises to facilitate structure/function analyses on the immune recognition of allergens. In addition, the wealth of information gathered on structure and genomic organization of allergens may prompt studies aiming at clarifying their function in the organisms of origin. By placing these proteins in their natural perspective, it is possible to achieve a more profound understanding of the basic mechanisms of allergy.


Allergic Patient Pollen Allergen Pollen Extract Major Allergen House Dust Mite Allergen 
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© Chapman & Hall 1996

Authors and Affiliations

  • Anna Ruffilli
  • Anna Scotto d’Ambusco
  • C. De Santo

There are no affiliations available

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