Lifespan Increase of Tumor-Bearing Mice Through Pretreatment

  • Leo Gross


In 1956, Barnothy, Barnothy, and Boszormenyi-Nagy1 reported the observation of leukocytosis in mice subsequent to a period of residence in magnetic fields of about 4000 Oe. Murphy2 in 1926 observed that the induction of lymphocytosis by a variety of agents such as low-level X-irradiation, dry heat, and injection of oils was accompanied by an extended survival and, in some cases, regression of an implanted tumor. That the lymphocyte is the active agent in this process is also confirmed by the results of Algire, Weaver, and Prehn,3 who found that transplants are not rejected when put in porous chambers in the peritoneum of mice. The chambers have barriers too small for lymphocytes or other cells to enter, but large enough to permit serum and fluid to pass.


Magnetic Field lymphOid Leukemia Magnetic Treatment Pole Piece Magnetic Field Exposure 
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  1. 1.
    Barnothy, J. M., M. F. Barnothy, and I. Boszormenyi-Nagy, “Influence of a Magnetic Field upon the Leukocytes of the Mouse,” Nature 177:577, 1956.CrossRefGoogle Scholar
  2. 2.
    Murphy, J. B., “The Lymphocyte vs. Resistance to Tissue Grafting, Malignant Disease and Tuberculous Infection,” Mono. # 21, Rockefeller Inst., Med. Res., 1926.Google Scholar
  3. 3.
    Algire, G. H., M. M. Weaver, and R. T. Prehn, “Studies on Tissue Homotransplantation in Mice Using Diffusion-Chamber Methods,” Ann. N. Y. Acad. Sci. 64:1009, 1957.CrossRefGoogle Scholar
  4. 4.
    Dunham, L. J., and H. L. Stewart, “A Survey of Transplantable and Transmissible Animal Tumors,” J. Natl. Cancer Inst. 13:1299, 1953.Google Scholar
  5. 5.
    Bailey, N. T. J., Statistical Methods in Biology, John Wiley & Sons, New York, 1959.Google Scholar

Copyright information

© Plenum Press 1964

Authors and Affiliations

  • Leo Gross
    • 1
  1. 1.Waldemar Medical Research FoundationWoodburyUSA

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