Reduction of Irradiation Mortality Through Pretreatment
The effect of whole-body irradiation on rodents with lethal doses of X rays or gamma rays is one of the most widely investigated phenomena. The mortality depends on the total dose, intensity at which this dose is delivered, strain, sex, and age of the animal. The first observable symptom is a drastic drop in the number of circulating leukocytes. This drop is a direct consequence of bone marrow destruction. Both serial histologic studies and direct counts demonstrate the rapid loss of nucleated cells from the bone marrow. The animal’s failure to replenish the granulocytes, platelets, and erythrocytes from the circulating blood is primarily responsible for the death.
KeywordsInhomogeneous Field Spleen Weight Magnetic Treatment Vertical Magnetic Field Drastic Drop
Unable to display preview. Download preview PDF.