Hematological Changes in Mice

  • Madeleine F. Barnothy


In 1948 J. M. Barnothy concluded from experiments in which he placed mice in strong magnetic fields that the main biological effect of a magnetic field is, most probably, a general retardation of mitosis and, furthermore, that this effect, as is the case with other external agents, is greater in rapidly dividing cells.1 Prompted by these considerations, I. Boszormeny-Nagy suggested in 1956 that we should investigate the effect of magnetic fields upon hemopoietic organs. The lifespan of leukocytes in the circulating blood is short, of the order of one day.2 Should the magnetic field affect the leukocyte-producing organs, the leukocyte number would change and provide a suitable test of the retardation of mitotic activity.


Leukocyte Count Magnetic Treatment Small Cage Standard Cage Pulse Height Distribution 


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  1. 1.
    Barnothy, J.M., Biological Effects of Magnetic Fields, Medical Physics, Vol. 3, O. Glasser, ed., Yearbook Publishing Co., 1960, p. 61.Google Scholar
  2. 2.
    Mallery, O.T., and M. McCutcheon, Am. J. Med. Sci. 200:394, 1940.CrossRefGoogle Scholar
  3. 3.
    Barnothy, J.M., M. F. Barnothy, and I. Boszormeny-Nagy, “Influence of the Magnetic Field upon the Leukocytes of the Mouse,” Nature 177:577, 1956.CrossRefGoogle Scholar
  4. 4.
    Barnothy, J.M., and M. F. Barnothy, “Biological Effects of Magnetic Fields and the Radiation Syndrome,” Nature 181:1785, 1958.CrossRefGoogle Scholar
  5. 5.
    Gross, L., “An Effect of Magnetic Fields on Tumor Growth,” Abstract L8, Biophysical Society Meeting, 1960.Google Scholar
  6. 6.
    Mattern, C. F., F. S. Brackett, and B. J. Olson, “Determination of Number and Size of Particles by Electronic Gateing,” J. Appl. Physiol. 10:56, 1957.Google Scholar
  7. 7.
    Akeroyd, J.H., et al., “On Counting Leukocytes by Electronic Means,” Am. J. Clin. Pathol. 31:188, 1959.Google Scholar
  8. 8.
    Richar, W.J., and E. S. Breakell, “Evaluation of an Electronic Particle Counter for the Counting of White Blood Cells,” Am. J. Clin. Pathol. 31:384, 1959.Google Scholar
  9. 9.
    Balazs, T., H.C. Grice, and J.M. Airth, “On Counting the Blood Cells of the Rat with an Electronic Counter,” Can. J. Comp. Med. 24:273, 1960.Google Scholar
  10. 10.
    Barnothy, J., and M. Forro, “Lethal Effect of Cosmic Ray Showers on the Progeny of Animals,” Experientia 4:1, 1948.CrossRefGoogle Scholar
  11. 11.
    Riley, V., “Rapid Orbital Bleeding Technic,” Proc. Soc. Exptl. Biol. Med. 104:751, 1960.Google Scholar
  12. 12.
    Casey, A. E., “The Diurnal Levels of Blood Leukocytes in the Normal Rabbit,” Proc. Soc. Exptl. Biol. Med. 45:863, 1940.Google Scholar
  13. 13.
    Kennon, B., M. E. Shipp, and D.C. Hetherington, “A Study of the White Blood Cell Picture in Six Young Men,” Am. J. Physiol. 118:690, 1937.Google Scholar
  14. 14.
    Garrey, W. E., and W.R. Bryan, “Variations in White Blood Cell Counts,” Physiol. Rev. 15:597, 1935.Google Scholar
  15. 15.
    Brown, F. A., Jr., R. O. Freeland, and C. L. Ralph, “Persistent Rhythms of 02-Consumption in Potatoes, Carrots, and the Seaweed, Fucus,” Plant Physiol. 30:280, 1955.CrossRefGoogle Scholar
  16. 16..
    Patt, H. M., and M. A. Maloney, “An Evaluation of Granulocytopoiesis,” Guiness Symp. on Cell Proliferation, Dublin, Eire, Aug. 14–15, 1962 (in press).Google Scholar

Copyright information

© Plenum Press 1964

Authors and Affiliations

  • Madeleine F. Barnothy
    • 1
  1. 1.College of PharmacyUniversity of IllinoisUSA

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