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Optimisation of a MS-Membrane Probe for the Measurement of Acetoin and Butanediol

  • M. Griot
  • E. Heinzle
  • I. J. Dunn
  • J. R. Bourne

Abstract

Mixing on the macro and also micro-scale and mass transfer may have a profound influence on productivity and yields especially so in large-scale fermentations. Scaling-up of fermentation processes often can only be done with great uncertainty usually only in an empirical manner.

Keywords

Response Time Bacillus Subtilis Dissolve Oxygen Concentration Step Change Agitation Speed 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bourne, J.R., 1983, Mixing on the Molecular Scale (Micro-mixing), Chem. Eng. Sci., 11: 1.Google Scholar
  2. Doerner, P., Lehmann, J., Piehl, H. and Megnet, R., 1982, Process Analysis of the Acetone-Butanol Fermentation by Quadrupole Mass Spectrometry, Biotechnol. Letters, 4: 557–562.CrossRefGoogle Scholar
  3. Furukawa, K.,Heinzle, E. and Dunn, I.J., 1983, Influence of Oxygen on the Growth of Saccharomyces cerevisiae in Continuous Culture, Biotechnol. Bioeng., 25: 2293.CrossRefGoogle Scholar
  4. Griot, M., Moes, J., Heinzle, E., Dunn, I.J. and Bourne, J.R., 1986, “A Microbial Culture for the Measurement of Micro Mixing Phenomena”, in: “Biological Reactors, Int. Conf. on Bioreactor Fluid Dynamics”, Cambridge, England, April 1986, Proceedings BHRA.Google Scholar
  5. Heinzle, E., Furukawa, K., Dunn, I.J. and Bourne, J.R., 1983, Experimental Methods for On-line Mass Spectrometry in Fermentation Technology, Bio/technology, 1: 181.CrossRefGoogle Scholar
  6. Hwang, S.T. and Kammermeyer, K., 1975, “Membranes in Separation”, J. Wiley & Sons ( Wiley Interscience ), New York.Google Scholar
  7. Moes, J., Griot, M., Keller, J., Heinzle, E., Dunn, I.J. and Bourne, J.R., 1985, A Microbial Culture with Oxygen-Sensitive Product Distribution as a Potential Tool for Characterizing Bioreactor Oxygen Transport. Biotechnol. Bioeng., 27: 482.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Griot
    • 1
  • E. Heinzle
    • 1
  • I. J. Dunn
    • 1
  • J. R. Bourne
    • 1
  1. 1.Chemical Engineering DepartmentETHZürichSwitzerland

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