Developments in Mass Spectrometric Instrumentation Relevant to Biotechnology

  • E. R. Schmid


In many disciplines the successful application of Mass Spectrometry (MS) has steadily increased. This holds also true for biotechnology. The reason for this is that mass spectrometry can be applied to all elements and to molecules with molecular weights greater than 15.000 dalton. The response is linear over many orders of magnitude, and it is an extremely sensitive method which needs only very small sample amounts.


High Performance Liquid Chromatography Ionization Method Fast Atom Bombardment Mass Spectrometry Field Desorption Computer Assisted Operation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Beckey, H.D., 1977, “Principles of Field Ionization and Field Desorption Mass Spectrometry,” Pergamon, London.Google Scholar
  2. Biemann, K., 1986, Mass Spectrometric Methods for Protein Sequencing, Analytical Chemistry, 58: 1288A.Google Scholar
  3. Bohatka, S., Szilagyi, J., and Langer, G., 1986, Application of MS to Industrial Fermentation, This bookGoogle Scholar
  4. Cox, R., 1986 “Design and Properties of Autoclavable Membrane-Covered Inlets for Continuous MS Measurements of Hydrophobic Compounds and Dissolved Gases”, This bookGoogle Scholar
  5. Griot, M., Dunn, I.J., and Heinzle, E., 1986, “Optimization of a MS-Membrane Probe for Measurement of Acetoin and Butanediol in Bacillus subtilis Fermentation,” This bookGoogle Scholar
  6. Henneberg, D., 1980, “Computerization and Library Search Systems,” in: “Advances in Mass Spectrometry,” A.Quayle, ed., Heyden & Son Ltd., London.Google Scholar
  7. Mamyrin, B.A., Karatajev, V.J., Shmikk, D.V., and Zagulin, V.A., 1973, Sov. Phys.-Tetp., ( Engl. Transi. ), 37: 45.Google Scholar
  8. McLafferty, F.W., 1983, A, “Tandem Mass Spectrometry,” John Wiley & Sons, New York, Chichester.Google Scholar
  9. McLafferty, F.W., Cheng, S., Dully, K.M., Guo, C.-J., Mun, I.K., Peterson, D.W., Russo, S.O., Salvucci, D.A., Serum, J.W., Staedeli, W., and Stauffer, D.B., 1983, B, “Matching Mass Spectra Against a Large Data Base During GC/MS Analysis”, Int. T. Mass Spectrom. Ion Phys. 47: 317.Google Scholar
  10. Schmid, E.R., Fogy, I., and Kenndler, E., 1977, “Beitrag zur Unterscheidung von Gärungsessig und synthetischen Säureessig durch die Bestimmung der spezifischen 14C-Radioaktivität”, Z. Lebensm. Unters.-Forsch., 163: 121.Google Scholar
  11. Schmid, E.R., Fogy, I., and Schwarz, P., 1978, “A Method for Differentiating Between Vinegar Produced by Fermentation and Vinegar Made from Synthetic Acetic Acid Based on Determination of the 13C/12C- Isotope Ratio by Mass Spectrometry,” Z. Lebensm. Unters.-Forsch., 166: 89.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • E. R. Schmid
    • 1
  1. 1.Institute for Analytical ChemistryUniversity of ViennaViennaAustria

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