The Use of Mass Spectrometry in the Screening of Microorganisms on Productivity

  • Marcel W. W. M. van Tilborg


Quantitative measurement of volatile compounds in a complex matrix may cause serious analytical problems. In this case the production of ethanol (p.p.m. level) in an environment already containing ethanol (percentages), had to be measured.

Using the isotope dilution method GC-MS failed due to chemical noise and the lack of high resolution (resolution power needed was 40.000). This article describes a fast GC-MS-MS method, using a simple, medium resolution double focussing mass spetrometer. This method has the advantage that no sample pretreatment is necessary, meaning the whole analysis may be performed in less than 5 minutes.


Volatile Compound Ethanol Production High Resolution Mass Spectrometry Isotope Dilution Method Chemical Noise 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Marcel W. W. M. van Tilborg
    • 1
  1. 1.Gist-brocades, Analytical DepartmentDelftThe Netherlands

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