Control of Protein Synthesis Initiation Factor eIF-2α Phosphorylation by Interferon
This paper is intended to cover the main points of the lecture which was presented on interferon and eIF-2α phosphorylation as part of the Spetsai Summer School Course on “Signal Transduction and Protein Phosphorylation”. It was impossible to cover this field in the time allotted, therefore this manuscript should be viewed as a limited introduction to the field. The goal of the talk was 3-fold. First, to briefly describe the effect of viral infection on protein synthesis and how pretreatment with interferon protects the cell against this response. Secondly, to review experiments which led to the finding that pretreatment of cells with interferon induces the synthesis of a protein kinase which phosphorylates the α subunit of protein synthesis initiation factor eIF-2. Finally, to discuss recent results leading to the identification of the molecular components of the kinase complex and the role that each of these components may play in the kinase response.
KeywordsProtein Synthesis Kinase Complex Protein Synthesis System Kinase Response Protein Synthesis Initiation
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