Abstract
Interleukin 1 (IL-1) is a protein produced mainly by activated mononuclear phagocytes which mediates the accessory cell requirement in the activation cascade of T-lymphocytes. The purification and molecular cloning of at least two different genes for IL-1 made larger amounts of the molecule available and thus it became apparent that the IL-1s have a multitude of functions besides the central role in the immune system, which can be summarized in their regulatory function in the inflammatory response (for a review see (1)). Despite this pivotal role of IL-1 in regulating the metabolism and controlling the growth of a variety of target cells, very few data are available concerning the ways of signal transduction involved.
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References
J.J. Oppenheim., E.J. Kovacs, K. Matsushima, and S.K. Durum, There is more than one Interleukin 1, Inmiunology Today 7:45 (1986)
D.H. Lovett, B. Kozan, M. Hadam, K. Resch, and D. Gemsa, Macrophage Cytotoxicity: Interleukin 1 as a mediator of tumor cytostasis, J.Immunol. 136:340 (1986)
J.A. Schmidt, S.B. Mizel, D. Cohen, and I. Green, Interleukin 1, a potential regulator of fibroblast proliferation, J.Immunol. 128:2177 (1982)
D.H. Lovett, J.L. Ryan, and R.B. Sterzei, Stimulation of rat mesangial cell proliferation by macrophage interleukin 1, J. Immunol. 131:2830 (1983)
V. Kaever, M. Szamel, M. Goppelt, and K. Resch, Characterization and subcellular localization of nucleotide cyclase in calf lymphocytes, Biochim.Biophys.Acta 776:133 (1984)
S.B. Mizel and D. Mizel, Purification to apparent homogeneity of murine interleukin 1, J.Immunol. 126:834 (1981)
U.K. Laemmli, Cleavage of the structural proteins during assembly of the head of bacteriophage T4, Nature 227: 680 (1970)
M. Martin, D.H. Lovett, and K. Resch, Interleukin 1 induces specific phosphorylation of a 41 kDa plasma membrane protein from the human tumor cell line K 562, Immunobiol. 171:165 (1986)
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© 1987 Plenum Press, New York
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Martin, M., Kyas, U., Resch, K. (1987). Interleukin 1 Induces Tyrosine Phosphorylation in Plasma Membranes of the Tumor Cell Lines K 562 and BW 5147. In: Heilmeyer, L.M.G. (eds) Signal Transduction and Protein Phosphorylation. NATO ASI Series, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0166-1_46
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DOI: https://doi.org/10.1007/978-1-4757-0166-1_46
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0168-5
Online ISBN: 978-1-4757-0166-1
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