Interleukin 1 Induces Tyrosine Phosphorylation in Plasma Membranes of the Tumor Cell Lines K 562 and BW 5147

  • Michael Martin
  • Urte Kyas
  • Klaus Resch
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 135)


Interleukin 1 (IL-1) is a protein produced mainly by activated mononuclear phagocytes which mediates the accessory cell requirement in the activation cascade of T-lymphocytes. The purification and molecular cloning of at least two different genes for IL-1 made larger amounts of the molecule available and thus it became apparent that the IL-1s have a multitude of functions besides the central role in the immune system, which can be summarized in their regulatory function in the inflammatory response (for a review see (1)). Despite this pivotal role of IL-1 in regulating the metabolism and controlling the growth of a variety of target cells, very few data are available concerning the ways of signal transduction involved.


Plasma Membrane Protein Plasma Membrane Vesicle Phosphoamino Acid Tyrosine Phosphate Purify Plasma Membrane 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Michael Martin
    • 1
  • Urte Kyas
    • 1
  • Klaus Resch
    • 1
  1. 1.Div. of Molecular PharmacologyMedical School HannoverHannover 61FRGermany

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