Interleukin 1 Induces Tyrosine Phosphorylation in Plasma Membranes of the Tumor Cell Lines K 562 and BW 5147
Interleukin 1 (IL-1) is a protein produced mainly by activated mononuclear phagocytes which mediates the accessory cell requirement in the activation cascade of T-lymphocytes. The purification and molecular cloning of at least two different genes for IL-1 made larger amounts of the molecule available and thus it became apparent that the IL-1s have a multitude of functions besides the central role in the immune system, which can be summarized in their regulatory function in the inflammatory response (for a review see (1)). Despite this pivotal role of IL-1 in regulating the metabolism and controlling the growth of a variety of target cells, very few data are available concerning the ways of signal transduction involved.
KeywordsPlasma Membrane Protein Plasma Membrane Vesicle Phosphoamino Acid Tyrosine Phosphate Purify Plasma Membrane
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