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Interleukin 1 Induces Tyrosine Phosphorylation in Plasma Membranes of the Tumor Cell Lines K 562 and BW 5147

  • Michael Martin
  • Urte Kyas
  • Klaus Resch
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 135)

Abstract

Interleukin 1 (IL-1) is a protein produced mainly by activated mononuclear phagocytes which mediates the accessory cell requirement in the activation cascade of T-lymphocytes. The purification and molecular cloning of at least two different genes for IL-1 made larger amounts of the molecule available and thus it became apparent that the IL-1s have a multitude of functions besides the central role in the immune system, which can be summarized in their regulatory function in the inflammatory response (for a review see (1)). Despite this pivotal role of IL-1 in regulating the metabolism and controlling the growth of a variety of target cells, very few data are available concerning the ways of signal transduction involved.

Keywords

Plasma Membrane Protein Plasma Membrane Vesicle Phosphoamino Acid Tyrosine Phosphate Purify Plasma Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Michael Martin
    • 1
  • Urte Kyas
    • 1
  • Klaus Resch
    • 1
  1. 1.Div. of Molecular PharmacologyMedical School HannoverHannover 61FRGermany

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