Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells
Recently I have shown that vasoconstrictive hormones, such as angiotensin II, vasopressin and norepinephrine, caused a rapid hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) in rat mesangial cells with subsequent formation of diacylglycerol (DG) and inositoltrisphosphate (IP3) (1, 2). The activation of phospholipase C, which accounted for this degradation of PIP2 further leads to an increased synthesis of prostaglandins (PG). The present study was carried out to gain information about the nature of the link between the occupation of the angiotensin II receptor and the activation of phospholipase C in mesangial cells.
KeywordsMesangial Cell Pertussis Toxin Inositol Phosphate PGE2 Synthesis Rapid Hydrolysis
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