Phosphorylation of Two Different forms of the Cytoskeletal Protein Caldesmon by Protein Kinase C

  • David W. Litchfield
  • Eric H. Ball
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 135)


Tumour-promoting phorbol esters have been shown to cause cytoskeletal alterations in cultured cells (Rifkin et al., 1979; Schliwa et al., 1984). These compounds exert their biological effects by activation of protein kinase C (Ashendel, 1985; Nishizuka, 1986) suggesting that cytoskeletal changes may be brought about by the phosphorylation of regulatory components of the cytoskeleton.


Chicken Gizzard Cytoskeletal Alteration Type IIIS Inhibit Myosin Light Chain Kinase Phosphoamino Acid Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The Abbreviations used are


70–80 kDa caldesmon


140–150 kDa caldesmon


sodium dodecyl sulphate


polyacrylamide gel electrophoresis


protein kinase C


ethylene glycol bis (β-aminoethyl ether)-N,N,N′ ,N′-tetraacetic acid.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • David W. Litchfield
    • 1
  • Eric H. Ball
    • 1
  1. 1.Department of BiochemistryUniversity of Western OntarioLondonCanada

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