Skip to main content

Structure, Function and Regulation of Protein Phosphatase

  • Conference paper
Signal Transduction and Protein Phosphorylation

Part of the book series: NATO ASI Series ((NSSA,volume 135))

  • 134 Accesses

Abstract

In the opening lecture, the events surrounding the discovery that glycogen phosphorylase activity is regulated by phosphorylation-dephosphorylation were presented. Since that time, this type of protein modification has proved to be a major mechanism by which many eukaryotic cellular processes, including their metabolism, growth, differentiation, transformation and gene expression, can be regulated. We have already heard about the many advances that have been made in our understanding of the subunit structure, mechanism of action, functional sites and regulation of the cAMP-dependent protein kinase, of phosphorylase kinase, and several other kinases, including protein tyrosine kinases. Until recently, however, much less was known about the protein phosphatases that catalyse protein dephosphorylation. Reasons for this include: 1) difficulty in obtaining substrates since an appropriate phosphoprotein must first be isolated and then phosphorylated with a specific protein kinase, and 2) general instability, low intracellular concentrations, and broad specificity of the phosphatases in addition to their tendency to be affected by many allosteric agents. This has made it difficult to determine if one were working with a single phosphatase or a mixture of enzymes. Despite these problems, several phosphatases have now been purified and extensively studied and some of their properties will be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this paper

Cite this paper

Fischer, E.H., McNall, S.J., Tonks, N. (1987). Structure, Function and Regulation of Protein Phosphatase. In: Heilmeyer, L.M.G. (eds) Signal Transduction and Protein Phosphorylation. NATO ASI Series, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0166-1_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0166-1_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0168-5

  • Online ISBN: 978-1-4757-0166-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics