Advertisement

Modulation of Cardiac Ca Channels by Phosphorylation

  • W. Trautwein
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 135)

Abstract

Ca ions play an important role in signal transmission across the cell membrane and within the cell. In heart muscle they control the force of contraction and participate in the spontaneous impulse generation in the sinus node, the primary pacemaker, as well as in conduction across the atrio-ventricular node. Ca ions enter the cell through voltage-controlled Ca channels which open upon depolarization of the cell membrane giving rise to a Ca current into the cell. Two types of Ca channels have been found in heart cells. The T-type (T-for transient) is activated and rapidly inactivated at voltages far negative to those regulating the L-type (L-for low threshold) channel (1, 34, 35). The Ca current through the T-type channel is small in amplitude as compared to the current through the L-type channel and nothing is known as yet about its pharmacology and physiological control (1, 34). By contrast, the control of L-type Ca channels by ß-adrenergic stimulation or mucarinic inhibition has been quantitatively studied in recent years (20, 26, 47, for review). Evidence has been presented that phosphorylation of the L-type Ca channel glycoprotein is involved in this control.

Keywords

Adenylate Cyclase Catalytic Subunit Current Trace Intracellular Application Suction Pipette 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bean, B.P. (1985) J. Gen. Physiol. 86, 1–30.PubMedCrossRefGoogle Scholar
  2. 2.
    Beavo, J.A., Bechtel, B.J., Krebs, EG. (1974b) Proc. Natl. Acad. Sci. USA. 71, 3580–3583.PubMedCrossRefGoogle Scholar
  3. 3.
    Biegon, R., Epstein, P., Pappano, A. (1980) J. Pharmacol Exp. Ther. 215, 348–356.PubMedGoogle Scholar
  4. 4.
    Breitwieser, G., Szabo, G. (1985) Nature, 317, 538–540.PubMedCrossRefGoogle Scholar
  5. 5.
    Brum, G., Osterrieder, W., Trautwein, W. (1984) Pflügers Arch. 401, 111–118.CrossRefGoogle Scholar
  6. 6.
    Cachelin, A.B., De Peyer, J.E., Kokubun, S., Reuter, H. (1983). Nature, 304, 462–464.PubMedCrossRefGoogle Scholar
  7. 7.
    Cavalié, A., Ochi, R., Pelzer, D., Trautwein, W. (1983) Pflügers Arch. 398, 284–297.CrossRefGoogle Scholar
  8. 8.
    Cavalié, A., Pelzer, D., Trautwein, W. (1985) J. Physiol. Lond. 358, 59 P.Google Scholar
  9. 9.
    Cavalié, A., Pelzer, D., Trautwein, W. (1986) Pflügers Arch. 406, 241–258.PubMedCrossRefGoogle Scholar
  10. 10.
    Corbin, J.D., Keely, S.L. (1977) J. Biol. Chem. 252, 910–918.PubMedGoogle Scholar
  11. 11.
    Codina, J., Hildebrandt, J., Sunyer, T., Sekura, R., Manclark, C., lengar, R., Birnbaumer, L. (1984). Adv. Cyclic. Nucleotide Res. 17, 111–125.Google Scholar
  12. 12.
    Drummond, G.I., Severson, D.L. (1979) Circ. Res. 44, 145–153.PubMedCrossRefGoogle Scholar
  13. 13.
    Endoh, M. (1980) Naunyn-Schmiedeberg’s Arch. Pharmacol. 312, 175–182.Google Scholar
  14. 14.
    Flockerzi, V., Oeken, H.J., Hofmann F. (1986) Eur. J. Biochem. 155, 613–620.PubMedCrossRefGoogle Scholar
  15. 15.
    Flockerzi, V., Oeken, H.J., Hofmann, F., Pelzer, D., Cavalié, A., Trautwein, W. (1986) Nature, 323, 66–68.PubMedCrossRefGoogle Scholar
  16. 16.
    Gilman, A. (1984) Cell 36, 577–57917PubMedCrossRefGoogle Scholar
  17. 17.
    Glossmann, H., Ferry, D.R., Göll, A., Striessnig, J., Zernig, G. (1985) Arzneim-Forschung/Drug. Res. 35, 1917–1935.Google Scholar
  18. 18.
    Hamill, O.P., Marty, A., Neher, E., Sakmann, B., Sigworth, J. (1981) Pflügers Arch. 391, 85–100.CrossRefGoogle Scholar
  19. 19.
    Hanke, W., Methfessel, C., Wilmsen, U., Boheim, GC. (1984) Biolectrochem. Bioenerget. 12, 329–339.CrossRefGoogle Scholar
  20. 20.
    Hescheler, J., Kameyama, M., Trautwein, W. (1986) Pflügers Arch. 407, 182–189.PubMedCrossRefGoogle Scholar
  21. 21.
    Hess, P., Lansman, J.B., Tsien, R.W. (1984) Nature, 311, 538–544PubMedCrossRefGoogle Scholar
  22. 22.
    1ngebritzen, T.S., Cohen, P. (1983) Eur. J. Biochem. 132, 255–261.CrossRefGoogle Scholar
  23. 23.
    Lngebritzen, T.S., Stewart, A.A., Cohen, P. (1983) Eur. J. Biochem. 132, 297–307.CrossRefGoogle Scholar
  24. 24.
    Isenberg, G., Klockner, U. (1982) Pflügers Arch. 395, 30–41.CrossRefGoogle Scholar
  25. 25.
    Jacobs, K., Aktories, K., Schultz, G. (1979) Naunyn-Schmiedeberg’s Arch. Pharmacol. 310, 113–119.Google Scholar
  26. 26.
    Kameyama, M., Hofmann, F., Trautwein, W. (1985) Pflügers Arch. 405, 285–293.CrossRefGoogle Scholar
  27. 27.
    Kameyama, M., Hescheler, J., Hofmann, F., Trautwein, W. (1986) Pflügers Arch. 407, 123–128.PubMedCrossRefGoogle Scholar
  28. 28.
    Kameyama, M., Hescheler, J., Mieskes, G., Trautwein, W. (1986) Pflügers Arch. 407, 461–463.CrossRefGoogle Scholar
  29. 29.
    Keely, S., Lincoln, T., Corbin, J. (1978) Am. J. Physiol. 234(4), H432-H438.PubMedGoogle Scholar
  30. 30.
    Krebs, E.G., Beavo, J.A. (1979) Ann. Rev. Biochem. 48, 923–959.PubMedCrossRefGoogle Scholar
  31. 31.
    Linden, J., Hollen, C., Patel, A. (1985) Circ. Res. 56, 728–735.PubMedCrossRefGoogle Scholar
  32. 32.
    McDonald, T.F., Pelzer, D., Trautwein, W. (1984) J. Physiol. Lond. 352, 217–241.PubMedGoogle Scholar
  33. 33.
    McDonald, T.F., Cavalié, A., Trautwein, W., Pelzer, D. (1986) Pflügers Arch. 406, 437–448.CrossRefGoogle Scholar
  34. 34.
    Mitra, R., Morad, M. (1986) Proc. Natl. Acad. Sci. USA, 83, 5340–5344.PubMedCrossRefGoogle Scholar
  35. 35.
    Nilius, B., Hess, P., Lansmann, J., Tsien, R.W. (1985) Nature (London) 316, 443–446.CrossRefGoogle Scholar
  36. 36.
    Ochi, R. (1981) Academic Press New York, pp 79–86.Google Scholar
  37. 37.
    Palade, P.T., Aimers, W. (1985) Pflügers Arch. 405, 91–101.CrossRefGoogle Scholar
  38. 38.
    Reuter, H., (1983) Nature, 301, 569–574.PubMedCrossRefGoogle Scholar
  39. 39.
    Rodbell, M. (1980) Nature 284, 151–159.CrossRefGoogle Scholar
  40. 40.
    Ruth, P., Flockerzi, V., Nettelbladt, E., Oeken, J., Hofmann, F. (1985) Eur. J. Biochem. 150, 313–322.PubMedCrossRefGoogle Scholar
  41. 41.
    Ruth, P., Flockerzi, V., Oeken, H.J., Hofmann, F. (1986) Eur. J. Biochem. 155, 613–620.PubMedCrossRefGoogle Scholar
  42. 42.
    Sakmann B., Neher, E. (eds) Single Channel Recording, Plenum (New York).Google Scholar
  43. 43.
    Selinger, Z., Cassel, D. (1981) Adv. Cyclic Nucleotide Res. 14, 15–22.PubMedGoogle Scholar
  44. 44.
    Trautwein, W. (1987) Circ. Res. (in press).Google Scholar
  45. 45.
    Tsien, R.W. (1977) Adv. Cyclic. Nucleotide Res. 8, 363–420.PubMedGoogle Scholar
  46. 46.
    Tsien, R.W. (1983) Ann. Rev. Physiol. 45, 341–358.CrossRefGoogle Scholar
  47. 47.
    Tsien, R.W., Bean, B.P., Hess, P., Lansman, J.B., Nilius, B., Novicky, M.C. (1986) J. Mol. Cell Cardiol. 18, 691–710.PubMedCrossRefGoogle Scholar
  48. 48.
    Ui, M. (1984) TIPS (1984) 277–279.Google Scholar
  49. 49.
    West, R., Moss, J., Vaughan, M., Liu, T., Liu, T.Y. (1986) J. Biol. Chem. 260, 15718–15722.Google Scholar
  50. 50.
    Wolff, J., Hope Cook, G., Goldhammer, A., Londons, C., Hewlett, E. (1984) Adv. Cyclic Nucleotide Res. 17, 161–172.Google Scholar
  51. 51.
    Yount, R.G. (1975) Adv. Enzymol. 34, 1–56.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • W. Trautwein
    • 1
  1. 1.II. Physiologisches InstitutUniversität des SaarlandesHomburg/SaarGermany

Personalised recommendations