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ADP-Ribosylation of Actin by Botulinum C2 Toxin

  • Klaus Aktories
  • Michael Bärmann
  • Monika Laux
  • Karl Heinrich Reuner
  • Peter Presek
  • Beate Schering
Part of the NATO ASI Series book series (NSSA, volume 135)

Abstract

The ADP-ribosylation of proteins is an important patho-physiological mechanism by which various microbial toxins affect eucaryotic cell functions. Well-studied examples of this group of toxins are cholera-, pertussis- and diphtheria toxins (1, 2). Whereas cholera toxin and pertussis toxin interfere with the hormon-sensitive adenylate cyclase by ADP-ribosylating the regulatory Ns and Ni-proteins of the adenylate cyclase system, respectively, diphtheria toxin is known to inhibit the protein synthesis by ADP-ribosylation of elongation factor 2.

Keywords

Botulinum Toxin Intact Cell Cholera Toxin Pertussis Toxin Diphtheria Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Klaus Aktories
    • 1
  • Michael Bärmann
    • 1
    • 2
  • Monika Laux
    • 1
  • Karl Heinrich Reuner
    • 1
  • Peter Presek
    • 1
  • Beate Schering
    • 1
  1. 1.Rudolf-Buchheim-InstitutGießenGermany
  2. 2.Institut für Toxikologie und PharmakologieUniversität GießenGießenGermany

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