ADP-Ribosylation of Actin by Botulinum C2 Toxin
The ADP-ribosylation of proteins is an important patho-physiological mechanism by which various microbial toxins affect eucaryotic cell functions. Well-studied examples of this group of toxins are cholera-, pertussis- and diphtheria toxins (1, 2). Whereas cholera toxin and pertussis toxin interfere with the hormon-sensitive adenylate cyclase by ADP-ribosylating the regulatory Ns and Ni-proteins of the adenylate cyclase system, respectively, diphtheria toxin is known to inhibit the protein synthesis by ADP-ribosylation of elongation factor 2.
KeywordsBotulinum Toxin Intact Cell Cholera Toxin Pertussis Toxin Diphtheria Toxin
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