Regulation of Muscle Contraction
Contraction in muscle is associated with a high rate of hydrolysis of ATP by actomyosin. In all types of muscle the two protein components of the contractile system are located in different structures, the thin actin filaments and the thick myosin filaments. The substrate for contraction. MgATP, is a poor substrate for myosin alone but when it interacts with actin it is split at a high rate. Thus regulation involves controlling the interaction of actin with myosin that activates the MgATPase and leads to contraction.
KeywordsThin Filament Myosin Light Chain Kinase Calcium Sensitivity Actin Monomer Myosin Molecule
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