Regulation of Muscle Contraction

  • S. V. Perry
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 135)


Contraction in muscle is associated with a high rate of hydrolysis of ATP by actomyosin. In all types of muscle the two protein components of the contractile system are located in different structures, the thin actin filaments and the thick myosin filaments. The substrate for contraction. MgATP, is a poor substrate for myosin alone but when it interacts with actin it is split at a high rate. Thus regulation involves controlling the interaction of actin with myosin that activates the MgATPase and leads to contraction.


Thin Filament Myosin Light Chain Kinase Calcium Sensitivity Actin Monomer Myosin Molecule 
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  1. Kakiuchi, S. and Sobue, K, 1983, Control of the cytoskeleton by calmodulin and calmodulin binding proteins, Trends in Biochemical Sciences 8: 59.CrossRefGoogle Scholar
  2. Lehman, W., 1978, Thick filament calcium regulation in vertebrate striated muscle. Nature 274: 80.PubMedCrossRefGoogle Scholar
  3. Lehman, W., Kendrick-Jones, J. and Szent-Gyorgyi, A.G., 1972, Myosin linked regulatory systems: Comparative Studies, Cold Spring Harbor Symposium on Quantitative Biology, 37: 319.Google Scholar
  4. Nonomura, Y. and Ebashi, S., 1980, Calcium regulatory mechanisms in vertebrate smooth muscle. Biomedical Research 1: 1.Google Scholar
  5. Sysila, H., Wilkinson, J.M., Grand, R.J.A. and Perry, S.V., 1976, The relationship between biological activity and primary structure of troponin I from white skeletal muscle of the rabbit, Biochem. J., 153: 375.Google Scholar


  1. Bretscher, A.J., 1986, Thin filament regulatory proteins of smooth and non-muscle cells, Nature 321: 726.PubMedCrossRefGoogle Scholar
  2. England, P.J., 1983, Phosphorylation of cardiac muscle contractile proteins. In Cardiace Metabolism (Drake-Hoiland, A.J. and Noble, M.I.M., eds) John Wiley and Sons Ltd., 365.Google Scholar
  3. Hartshorne, D.J. and Siemankowski, R.F., 1981, Regulation of smooth muscle actomyosin, Ann. Rev. Physiol., 43: 519.CrossRefGoogle Scholar
  4. Marston, S.B. and Smith, C.W.J., 1985, Thin filaments of smooth muscles, J. Muscle Research and Cell Mobility 6: 669.CrossRefGoogle Scholar
  5. Perry, S.V., 1979, The regulation of contractile activity in muscle. Biochemical Society Transactions 7: 593.PubMedGoogle Scholar
  6. Perry, S.V., 1986, Activation of the contractile mechanism by calcium. In: Myology (Engel, A.G. and Banker, B.Q., eds) McGraw-Hill Book Company, New York, Part I, 613.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. V. Perry
    • 1
  1. 1.Department of Physiology Medical SchoolUniversity of BirminghamBirminghamUK

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