Sensitivity of a cAMP PDE to Rolipram in Different Organs
Manipulation of cAMP-dependent mechanisms in aminergic transmission by selective phosphodiesterase (PDE) inhibitors may provide a novel therapetic approach for the management of depression (Wachtel, 1983). The PDE inhibitor rolipram has been shown in recent clinical trials to possess antidepressant activity (Horowski and Sastre, 1985). Antidepressant drug therapy needs several days before relief of symptoms is observed. Time-dependent neuronal adaptation processes may be based on an altered function of regulatory proteins, as e.g. resulting from protein phosphorylation. The therapeutic effect following rolipram treatment could therefore be explained by a mechanism involving a cAMP dependent protein kinase.
KeywordsAntidepressant Activity cAMP Dependent Protein Kinase Selective Phosphodiesterase Monophosphate Phosphodiesterase Crude Organ Extract
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