Neuromodulatory Actions of Dopamine and Cholecystokinin in the Ventral Striatum
Electrophysiological investigations of the cellular actions of dopamine had focused in the past on its direct action on cell bodies of the postsynaptic neuron, assuming dopamine to be a neuromediating transmitter. Recent evidence suggests, however, that while dopamine undoubtedly has actions on the cell bodies of postsynaptic neurons, it may also have an important presynaptic neuromodulatory action on non-dopaminergic inputs to the ventral striatum (see Yim and Mogenson, 1986). There is also evidence that peptides such as cholecystokinin which coexists with dopamine in a subpopulation of the mesolimbic dopamine neurons may in turn modulate the neuromodulatory action of dopamine.
KeywordsLocomotor Activity Nucleus Accumbens Ventral Tegmental Area Ventral Striatum Excitatory Response
Unable to display preview. Download preview PDF.
- Ferron, A., Thierry, A.M., Le-Douarin, C., and Glowinski, J., 1984, Inhibitory influence of the mesocortical dopaminergic system on spontaneous activity or excitatory response induced from the thalamic mediodorsal nucleus in the rat medial prefrontal cortex. Brain Res., 302:257–265.PubMedCrossRefGoogle Scholar
- Hokfelt, T., Skirboll, L., Rehfeld, J., Goldstein, M., Marley, K., and Dann, O., 1980, A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: evidence from immunohistochemistry combined with retrograde tracing, Neuroscience, 5:2093–2124.PubMedCrossRefGoogle Scholar
- Kaczmarek, L.K. and Levitan, I.B. 1987, Neuromodulation, Oxford University Press, New York.Google Scholar
- Kitai, S.T., Sugimori, M., and Kocsis, J.D., 1976, Excitatory nature of dopamine in the nigro-caudate pathway. Brain Res., 24:351–363.Google Scholar
- Markstein, R., and Hokfelt, T., 1984, Effect of cholecystokinin-octa- peptide on dopamine release from slices of cat caudate nucleus, J. Neuro. sci., 4:570–575.Google Scholar
- Mogenson, G.J., 1977, The Neurobiology of Behavior: An Introduction, Erlbaum.,Hillsdale., 1:Google Scholar
- Mogenson, G.J., 1987, Limbic-Motor Integration, in: “Progress in Psychobiology and Physiological Psychology,” A.N. Epstein, ed., Academic Press Inc., New York, p. 117–170.Google Scholar
- Skirboll, L.R., Grace, A.A., Hommer, D.W., Rehfeld, J., Goldstein, M., Hokfelt, T., and Bunney, B.S., 1981, Peptide-monoamine coexistence: studies of the actions of cholecystokinin-like peptides on the electrical activity of midbrain dopamine neurons, Neuroscience, 6:2111–2124.PubMedCrossRefGoogle Scholar
- Van Ree, J.M., Gaffori, O., and De Wied, D., 1983, In rats the behavioral profile of CCK-8-related peptides resembles that of antipsychotic agents, Eur. J. Pharmacol., 93:65–78.Google Scholar