Basal Forebrain Involvement in Self-Administration of Drugs of Abuse
There are a wide variety of chemical substances that have been classified as abused drugs on the basis of their excessive or inappropriate use. Although they may have distinct neurochemical actions and come from different pharmacological classes, what these drugs have in common is their capacity to engender pleasurable feelings or sensations in those individuals that use them. It is commonly believed that it is this property, their euphorigenic action, that causes their abuse.
KeywordsNucleus Accumbens Ventral Tegmental Area Medial Prefrontal Cortex Brain Stimulation Reward Neuroanatomical Substrate
Unable to display preview. Download preview PDF.
- Dworkin, S.I., Goeders, N.E., Guerin, G.F., Co, C., and Smith, J.E., 1988a, Effects of 5,7-dihydoxytrptamine lesions of the nucleus accumbens in rats responding on a concurrent schedule of food, water, and intravenous morphine self-administration, in: “Problems of drug dependence,” L. Harris, ed., NIDA Research Monograph No. 81, Washington, D.C., p. 138.Google Scholar
- Glick, S.D., 1974, Changes in sensitivity to the rewarding property of morphine following lesions of the medial forebrain bundle or caudate nucleus in rats. Arch. Int. Pharmacodvn. Therap., 212:214.Google Scholar
- Koob, G.F. and Goeders, N.E., 1989, Neuroanatomical substrates of drug self-administration, in: “The Neuropharmacological Basis of Reward,” J.M. Liebman and S.J. Cooper, ed., Clarendon Press, Oxford, p. 214.Google Scholar
- Koob, G.F., Vaccarino, F.J., Amalric, M., and Bloom, F.E., 1987, Positive reinforcement properties of drugs: search for neural substrates, in: “Brain reward systems and abuse,” J. Engel and L. Oreland, ed., Raven, New York, p. 35.Google Scholar
- Martin-Iverson, M.T., Szostak, C., and Fibiger, H.C., 1986, 6-Hydroxydopamine lesions of the medial prefrontal cortex fail to influence intravenous self-administration of cocaine, Psychopharmacologv. 88:310.Google Scholar
- Pontieri F.E., Crane, A.M., Seiden, L.S., Kleven, M.S., and Porrino, L.J., Metabolic mapping of the effects of intravenous methamphetamine administration in freely-moving rats. Psychopharmacology. in Press.Google Scholar
- Smith, J.E., Dworkin, S.I., Co, C., and Porrino, L.J., 1990, Concurrent brain glucose utilization and biogenic monoamine neurotransmitter turnover rates with VTA brain stimulation reinforcement. Soc. Neurosci. Abstr. 19, in press.Google Scholar
- Sokoloff, L., Reivich, M., Kennedy, C., DesRosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O., and Shinohara, M., 1977, The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897.PubMedCrossRefGoogle Scholar