Basal Forebrain Modulation of Cortical Cell Activity During Conditioning
Several investigators have found that basal forebrain neurons in the area of the nucleus basalis and substantia innominata respond to cues that signal the availability of reinforcement (DeLong, 1971; Mitchell et al., 1987; Richardson and DeLong, 1986, 1988; Rolls et al., 1979; Travis and Sparks, 1968; Wilson and Rolls, 1990a, 1990b). The reinforcement-related or conditioning-related responses of such basal forebrain neurons do not depend upon the sensory modality of the signal cue (Wilson and Rolls, 1990a). It is also known that cortical neurons respond to conditioned stimuli applied during similar behavioral paradigms (Aou et al., 1983; Boyd et al., 1982; Fuster et al., 1982; Kojima and Goldman-Rakic, 1982; Mauritz and Wise, 1986; Peterson, 1986; Watanabe, 1990), suggesting a possible relationship between cortical neuron responses and activity of basal forebrain neurons.
KeywordsConditioned Stimulus Basal Forebrain Nucleus Basalis Substantia Innominata Basal Forebrain Neuron
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- Ebenezer, I.S., 1983, Cortical slow potentials recorded in rats anesthetized with urethane are affected by nicotine, British J. Pharmacol. Proceed. Suppl., 79:270P.Google Scholar
- Pirch, J.H., 1990, Basal forebrain neuron responses during right eye vs. left eye light discrimination, Soc. Neurosci. Abstr., In Press.Google Scholar
- Pirch, J.H., Yadon, D., and Turco, K., 1989, Acetylcholine (ACh) role in conditioning-related responses of cortical neurons: Microiontophoretic studies, FASEB Journal., 3:A394.Google Scholar
- Rye, D.B., Wainer, B.H., Mesulam, M.-M., Mufson, E.J., and Saper, C.B., 1984, Cortical projections arising from the basal forebrain: a study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase, Neuroscience. 13:627.PubMedCrossRefGoogle Scholar
- Swartz, B.E., and Woody, C.D., 1979, Correlated effects of acetylcholine and cyclic guanosine monophosphate on membrane properties of mammalian neocortical neurons, J. Neurophysiol., 10:465.Google Scholar
- Turco, K., Yadon, D., and Pirch, J., 1988, Influence of microiontophoretic cholinergic drugs on conditioned cortical units, Soc. Neurosci. Abstr., 14:862.Google Scholar
- West, C.H.K., and Michael, R.P., 1989, Responses of mesolimbic units to sensory input in rats conditioned by reinforcing brain stimulation, Soc. Neurosci. Abstr., 15:1012.Google Scholar
- West, C.H.K., Schaefer, G.J., and Michael, R.P., 1990, Responses of single units in dopamine terminal areas to odors conditioned by reinforcing brain stimulation, FASEB Journal. 4:A978.Google Scholar
- Wilson, D.A., and Sullivan, R.M., 1990, Olfactory associative conditioning in infant rats with brain stimulation as reward. I. Neurobehavioral consequences. Develop. Brain Res., 53:215.Google Scholar