The BRCA1 gene in sporadic breast and ovarian cancer
The majority of cases of breast and ovarian cancer appear to be sporadic; that is, they arise without a clear genetic susceptibihty because the cases lack an obvious inherited component. However, there are some families in which there are several affected individuals, indicating either a clustering of sporadic cases or an inherited genetic effect. In other, rarer families, there is a clear inherited susceptibility to either breast or ovarian cancer which can be traced through consecutive generations. In these families the disease usually occurs at an early age and often bilaterally. Interestingly, the risk of ovarian cancer is increased in relatives of women with breast cancer and vice versa. This observation suggests the existence of one or more genes which predispose to both breast and ovarian cancer .
KeywordsBreast Cancer Ovarian Cancer BRCAI Gene Sporadic Breast Cancer BRCAI Locus
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