Abstract
Transcriptionally directed gene therapy is a promising genetic mechanism for the treatment of cancer [1]. TGT is based on delivery of a gene that will be specifically expressed in cancer cells but not in normal cells by exploiting the transcriptional differences between normal and neoplastic cells. The delivered and expressed gene may then confer selective sensitivity to a chemotherapeutic agent, deliver another gene to enhance the immune response to the tumor or it may correct a genetic defect.
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References
Ruber, B.E., Richards, C.A. and Krenitsky, TA. (1991) Retro viral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. PNAS, 88, 8039–43.
Miller, A.D. and Rosman, G.J. (1989) Improved retroviral vectors for gene transfer and expression. Biotechniques, 7, 980–8.
Miller, D.G., Adam, M.A. and Miller, A.D. (1990) Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol, 10, 4239–42.
Schrewe, H., Thompson, J., Bona, M. et al. (1990) Cloning of the complete gene for carci- noembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.Mol Cell Biol, 10, 2738–48.
Warshaw, A.L. and Fernandez del Castillo, C. (1992) Pancreatic c arcinoma. N. Engl J. Med., 326,455–65.
Gullen, B. (1986) Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.Cell, 46,973–82.
Berger, J., Hauber, J., Hauber, R. et al. (1988) Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene, 66, 1–10.
Moolten, F.L. (1986) Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control study. Cancer Res., 46, 5276–81.
Tani, T., Kawashima, I., Furukawa, H. et al. (1987) Characterization of a silent gene for human pancreatic elastase I: structure of the 5’ flanking region. J. Biochem., 101,591–9.
Tani, T., Ohsumi, J., Mita, K. and Takiguchi, Y. (1988) Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning, J.Biol Chem., 263,1231–9.
Tan, M.H., Nowak, N.J., Loor., R. et al. (1986) Characterization of a new primary human pancreatic tumor line. Cancer Invest., 4, 15–23.
Miller, A.D. and Buttimore, C. (1986) Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol, 6, 2895–902.
Rosenberg, S.A., Aebersold, P., Cometta, K. et al. (1990) Gene transfer into humans: immunotherapy of patients with advanced melanoma using tumor-infiltrating lymphocytes modified by retroviral gene transduction.N. Engl J. Med., 323,570–8.
Culver, K.W., Ram, Z., Wallbridge, S. et al. (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumours. Science, 256, 1550–2.
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Via, D.F., Dimaio, J.M., Berend, K.R., Jordan, P.B., Lyerly, H.K. (1995). Carcinoembryonic antigen (CEA) promoter directed tissue specific gene expression in CEA expressing tumour cells. In: Sharp, F., Mason, P., Blackett, T., Berek, J. (eds) Ovarian Cancer 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0136-4_35
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DOI: https://doi.org/10.1007/978-1-4757-0136-4_35
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