Matrix metalloproteinases and their role in ovarian cancer
Basement membrane is a dense condensation of connective tissue found at the basal surface of all normal epithelial cells. It is a physically and chemically tough structure consisting of a lattice of type IV collagen around which other components such as proteoglycan and laminin are arranged. If a primary epithelial tumour is to metastasize to distant sites it is necessary for it to breach the basement membrane into the underlying mesothelium. Noninvasive carcinoma in situ is surrounded by a complete basement membrane, whilst this structure is absent from truly invasive carcinomas .
KeywordsOvarian Cancer Ovarian Carcinoma Tumour Stroma Ovarian Tumour Type Versus Collagen
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