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The European—Canadian study of paclitaxel in ovarian cancer. High vs low dose; long vs short infusion

  • K. D. Swenerton
  • E. A. Eisenhauer

Abstract

Paclitaxel (Taxol) has demonstrated activity in platinum pretreated ovarian cancer [1–]. Because of severe hypersensitivity reactions seen early in the evaluation of the drug, treatment protocols were developed which gave paclitaxel over 24 hours together with antiallergic premedication. This maneuver resulted in a decrease in the frequency of severe reactions, although many patients continued to experience mild symptoms [4]. Shorter outpatient infusions with premedication had not been evaluated and the question of their safety remained unknown.

Keywords

Ovarian Cancer Hypersensitivity Reaction Epithelial Ovarian Cancer Severe Reaction Advanced Ovarian Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • K. D. Swenerton
  • E. A. Eisenhauer

There are no affiliations available

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