Advertisement

Genetic epidemiology of familial ovarian cancer in Utah

  • D. E. Goldgar
  • K. Rowe
  • C. M. Lewis
  • M. McDonald
  • K. Gholami
  • L. Cannon-Albright
  • M. Skolnick

Abstract

Ovarian cancer is the fifth most common cancer in American women but their fourth leading cause of cancer death. Ovarian cancer will strike an estimated 1% of women in their lifetime and is usually fatal. Because of the high mortality associated with ovarian cancer, identification of individuals at increased risk is particularly important. Individuals at very high risk due to genetic susceptibility might consider prophylactic oophorectomy to prevent development of ovarian tumors.

Keywords

Breast Cancer Ovarian Cancer Male Breast Cancer Genetic Epidemiology Ovarian Cancer Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hildreth, N.G., Kelsey, J.L., Li, V.A. et al, (1991) An epidemiologic study of epithelial carcinoma of the ovary. Am. J. Epidemiol., 114, 398–405.Google Scholar
  2. 2.
    Schildkraut, J.M. and Thompson, W.D. (1988). Familial ovarian cancer: a population-based case-control study. Am. J. Epidemiol., 128, 456–66.PubMedGoogle Scholar
  3. 3.
    Hall, J.M., Lee, M.K., Newman, B. et al, (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science, 250,1684–9PubMedCrossRefGoogle Scholar
  4. 4.
    Narod, S.A., Feunsteun, J., Lynch, H.T. et al, (1991) Familial breast-ovarian cancer locus on chromosome 17ql2-q23. Lancet, 338,82–3.PubMedCrossRefGoogle Scholar
  5. 5.
    Easton, D.F., Bishop, D.T., Ford, D. et al, (1993) Genetic linkage analysis in familial breast and ovarian cancer — results from 214 families. Am. J. Hum. Genet., 52,678–701.PubMedGoogle Scholar
  6. 6.
    Feunteun, J., Narod, S.A., Lynch, H.T. et al, (1993) A breast-ovarian susceptibility gene maps to chromosome 17q21. Am. J. Hum. Genet., 52, 736–42.PubMedGoogle Scholar
  7. 7.
    Goldgar, D.E., Cannon-Albright, L.A., Oliphant, A.R. et al, (1993) Chromosome 17q linkage studies of 18 Utah breast cancer kindreds. Am. J. Hum. Genet., 52, 743–8.PubMedGoogle Scholar
  8. 8.
    Eccles, D., Cranston, G., Steel, C.M. et al, (1990) Allele losses on chromosome 17 in human epithelial ovarian carcinoma. Oncogene, 5, 1599–601.PubMedGoogle Scholar
  9. 9.
    Ehlen, T. and Dubeau, L. (1990) Loss of heterozygosity on chromosomal segments 3p, 6q and lip in human ovarian carcinomas. Oncogene, 5,219–22.PubMedGoogle Scholar
  10. 10.
    Lee, J.H., Kavanagh, J.J., Wildrick, D.M. et al, (1990) Frequent loss of heterozygosity on chromosomes 6q, 11 and 17 in human ovarian carcinomas. Cancer Res., 50,2724–8.PubMedGoogle Scholar
  11. 11.
    Daly, M.B. (1992) The epidemiology of ovarian cancer. Hematol Oncol Clin. N. Am., 6, 729–38.Google Scholar
  12. 12.
    Skolnick, M. (1980) The Utah genealogical data base: a resource for genetic epidemiology. In Banbury Report No 4: Cancer Incidence in Defined Populations, (eds J. Cairns, J.L. Lyon, M. Skolnick), Cold Spring Harbor Laboratory, New York, pp 285–97.Google Scholar
  13. 13.
    Claus, E.B., Risch, N. and Thompson, W.D. (1991) Genetic analysis of breast cancer in the Cancer and Steroid Hormone Study. Am. J. Hum. Genet., 48,232–42.PubMedGoogle Scholar
  14. 14.
    Lathrop, G.M., Lalouel, J.M., Julier, C. et al., (1985) Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am. J. Hum. Genet., 37,482–98.PubMedGoogle Scholar
  15. 15.
    Goldgar, D.E., Fields, P., Lewis, C.M. et al., (1992) A large kindred with 17q-linked susceptibility to breast and ovarian cancer: relationship between genotype and phenotype. Am. J. Hum. Genet., (Suppl.), A96.Google Scholar
  16. 16.
    Goldgar, D.E., Fields, P., Lewis, C.M. et al, (1994) A large kindred with 17q-linked breast and ovarian cancer: genetic, phenotypic and genealogical analysis. J. Nat. Cancer Inst., 86, 200–9.PubMedCrossRefGoogle Scholar

Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • D. E. Goldgar
  • K. Rowe
  • C. M. Lewis
  • M. McDonald
  • K. Gholami
  • L. Cannon-Albright
  • M. Skolnick

There are no affiliations available

Personalised recommendations