Abstract
The majority of patients with ovarian borderline tumors and invasive carcinoma stage I have excellent prognosis after surgical removal of the tumor. Nevertheless, nearly all of these patients have received adjuvant treatment, in the absence of prognostic factors to pinpoint the few patients at risk, who might benefit from this treatment. Less extended surgery (than the standard surgery performed) might suffice in many patients, thus allowing young women to remain fertile, if more precise prognostic factors could be identified [1–4].
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Dembo, A.J., Davy, M., Stenwig, A.E. et al, (1990) Prognostic factors in patients with stage I epithelial ovarian cancer.Obstet. Gynecol,., 75, 263–73.
Berek, J.S. (1990) Adjuvant therapy for earlystage ovarian cancer.N. Engl. J. Med., 322, 1076–8.
Young, R.C., Walton, L.A., Ellenberg, S.S. et al., (1990) Adjuvant therapy in stage I and stage II epithelial ovarian cancer. N. Engl. J. Med., 322,1021–7.
Finn, C.B., Luesley, D.M., Buxton, E.J. et al., (1992) Is stage I epithelial ovarian cancer overtreated both surgically and systemically? Results of a five-year cancer registry review. Br. J. Obstet. Gynecol., 99, 54–8.
Baak, J.P.A., Langley, F.A., Talerman, A. et al, (1987) The prognostic variability of ovarian tumor grading by different pathologists. Gynecol Oncol., 27,166–72.
Friedlander, M.L., Russell, P., Taylor, I.W. et al, (1984) Flow cytometric analysis of cellular DNA content as an adjunct to the diagnosis of ovarian tumours of borderline malignancy. Pathology, 16,301–6.
Kaern, J., Tropé, C., Kjorstad, K.E. et al, (1990) Cellular DNA content as a new prognostic tool in patients with borderline tumors of the ovary. Gynecol Oncol., 38,452–7.
Hedley, D.W., Friedlander, M.L., Taylor, I.W. et al, (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J. Histochem. Cytochem., 31,1333–5.
Fossa, S.D., Berner, A., Heiden, T. et al, (1992) DNA ploidy in cell nuclei from paraffinembedded material — comparison of results from two laboratories. Cytometry, 13,395–403.
Iversen, O.E., Skaarland, E. (1987) Ploidy assessment of benign and malignant ovarian tumors by flow cytometry. A clinicopathologic study. Cancer, 60, 82–7.
Kühn, W., Kaufmann, M., Feichter, G.E. et al, (1989) DNA flow cytometry, clinical and morphological parameters as prognostic factors for advanced malignant and borderline ovarian tumors. Gynecol Oncol., 33, 360–7.
Klemi, P.J., Joensuu, H., Mäenpää, J. et al, (1990) Influence of cellular DNA content on survival in ovarian carcinoma.Obstet. Gynecol., 65,200–4.
Erhardt, K., Auser, G., Björkholm, E. et al, (1984) Prognostic significance of nuclear DNA content in serous ovarian tumors. Cancer Res., 44,2198–202.
Dietel, M., Arps, H., Rohlff, A. et al, (1986) Nuclear DNA content of borderline tumors of the ovary: correlation with histology and significance for prognosis. Virchows Arch. (Pathol Anat.), 409, 829–36.
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Kaern, J., Tropé, C.G., Abeler, V., Pettersen, E.O. (1995). Cellular DNA content: the most important prognostic factor in patients with borderline tumors of the ovary. Can it prevent overtreatment?. In: Sharp, F., Mason, P., Blackett, T., Berek, J. (eds) Ovarian Cancer 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0136-4_18
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DOI: https://doi.org/10.1007/978-1-4757-0136-4_18
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