Management of low malignant potential ovarian tumors
The recognition of low malignant potential (LMP) or borderline ovarian tumors as a distinct pathological entity by the International Federation of Gynecology and Obstetrics was an attempt to add a needed degree of precision to the diagnosis of ovarian tumors . Despite this widely accepted improvement in histological diagnostic criteria, the behavior and prognosis of LMP tumors remain unpredictable and the appropriate treatment continues to be debated. The uncertainty in therapeutic decision making is complicated by several factors. The diagnosis of an LMP tumor is rarely made preoperatively, so the initial treatment plan is often made in the operating room by physicians unaccustomed to treating ovarian malignancies. Consultation with clinicians more experienced with these tumors is frequently not feasible. In addition, histological diagnosis by rapid frozen section of LMP tumors is often difficult and unreliable. Finally, the postoperative treatment of LMP tumors in the United States has been characterized by a wide variety of regimens, making comparisons of long term outcomes difficult.
KeywordsSurgical Staging Adnexal Mass Gynecologic Oncology Group Borderline Ovarian Tumor Malignant Ovarian Tumor
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- 1.Santesson, L. and Kottmeier, H.L. (1978) General classification of ovarian tumors. In Ovarian Cancer, Vol. II, (eds F. Gentil and A.C. Sunquierra), Springer-Verlag, New York, pp. 1–8.Google Scholar
- 7.Katsube, Y., Berg, J.W. and Silverberg, S.G. (1982) Epidemiologic pathology of ovarian tumors: a histopathologic review of primary ovarian neoplasms diagnosed in the Denver Standard Metropolitan Statistical area, 1 July-31 December 1969 and 1 July-31Google Scholar
- 21.Tholander, B., Taube, A., Lindgren, A. et al, (1990) Pretreatment serum levels of CA-125, carcino embryonic antigen, tissue polypeptide antigen and placental alkaline phosphatase in patients with ovarian carcinoma, borderline tumors, or benign adnexal masses: relevance for differential diagnosis. Gynecol Oncol., 39, 16–25.PubMedCrossRefGoogle Scholar
- 25.Bakri, Y.N. and Given, F.T. (1984) Normal pregnancy and deUvery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. Gynecol Oncol., 16, 414.Google Scholar
- 43.Yazig, R., Munoz, A.K., Sandstad, J. et al, (1991) Cisplatin based combination chemotherapy in the treatment of stage III ovarian epithelial tumors of low malignant potential. Eur. J. Gynec. Oncol., 6,451–5.Google Scholar
- 46.Russell, P. (1984) Borderline epithelial tumors of the ovary: a conceptual dilemma. Clin. Obstet. Gynecol., 11,259–76.Google Scholar