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Activation of human ovarian cancer cells: role of lipid factors in ascitic fluid

  • Y. Xu
  • G. B. Mills

Abstract

Normal cells proliferate in response to injury or to replace cells with a limited survival time. This is true for cells in the hematopoietic system and epithelial cells of the skin and bowel. It has been estimated that 1 million cell divisions per second are required for the replacement of lost cells. The proliferation of normal cells is regulated by the action of a number of polypeptide and lipid factors called growth factors [1–8]. These growth factors bind to specific cell surface receptors and transmit activation signals across the cell membrane. These signals initiate a limited number of intracellular biochemical cascades which in turn communicate with the nucleus, eventually leading to cellular proliferation [5–8]. In addition to positive growth signals, a series of proteins is involved in limiting cellular proliferation [9–10]. Several of these, such as p53 and the product of the retinoblastoma gene (RB), are more commonly known as tumor suppressor genes [9,10]. Finally, some activated cells are sensitized to a physiological process Known as programmed cell death or apoptosis [11–13]. Both the products of tumor suppressor genes and the products of the genes involved in programmed cell death must be overcome for a cell to divide.

Keywords

Ovarian Cancer Ovarian Cancer Cell Ascitic Fluid Ovarian Cancer Patient Lipid Mediator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • Y. Xu
  • G. B. Mills

There are no affiliations available

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